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D9150

2,3-二甲氧基-5-甲基-对苯醌

Name: 2,3-二甲氧基-5-甲基-<I>对</I>苯醌
Brand: SIGMA

apoptosis inducer

别名:

Coenzyme Q₀

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关于此项目

经验公式（希尔记法）:

C₉H₁₀O₄

化学文摘社编号:

605-94-7

分子量:

182.17

UNSPSC Code:

12352204

NACRES:

NA.51

PubChem Substance ID:

24894261

EC Number:

210-100-8

Beilstein/REAXYS Number:

1640422

MDL number:

MFCD00001595

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Quality Level

200

form

powder

mp

58-60 °C (lit.)

storage temp.

2-8°C

SMILES string

COC1=C(OC)C(=O)C(C)=CC1=O

InChI

1S/C9H10O4/c1-5-4-6(10)8(12-2)9(13-3)7(5)11/h4H,1-3H3

InChI key

UIXPTCZPFCVOQF-UHFFFAOYSA-N

General description

2,3-Dimethoxy-5-methyl-p-benzoquinone (Coenzyme Q₀ or DMM) is present in all the cells including neural cells.

Application

2,3-Dimethoxy-5-methyl-p-benzoquinone has been used:

as a tau protein fibrillization inducer to determine the regions of tau involved in the formation of paired helical filaments (PHFs)
as a component in buffer B for cytochrome oxidation assay with subsaturating light
in the RPMI-1640 medium for 2,3-bis-(2-methoxy-4-nitro-5-sulphenyl)-(2H)-tetrazolium-5-carboxanilide (XTT) assay to quantify antifungal activity

Coenzyme Q0 inhibits (via radical quenching) reactions of gamma-irradiation induced homolytic cleavage of O-glycoside bonds in polysaccharides. Coenzyme Q0 induces apoptosis and modulates the cell cycle in estrogen receptor negative breast cancer cells. It is toxic to other cells such as insulin producing cells.

Biochem/physiol Actions

2,3-Dimethoxy-5-methyl-p-benzoquinone (Coenzyme Q₀) interacts with tau protein and aids in the formation of filamentous structure.

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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XTT assay of antifungal activity

Loures FV and Levitz SM

PLoS Pathogens, 5(15), e1543-e1543 (2015)

In vitro tau fibrillization: mapping protein regions

Santa-Maria I, et al.

Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1762(7), 683-692 (2006)

The Photosynthetic Bacterial Reaction Center: Structure and Dynamics, 114-114 (2013)

"Yellow" laccase from Sclerotinia sclerotiorum is a blue laccase that enhances its substrate affinity by forming a reversible tyrosyl-product adduct.

Augustin C Mot et al.

PloS one, 15(1), e0225530-e0225530 (2020-01-22)

Yellow laccases lack the typical blue type 1 Cu absorption band around 600 nm; however, multi-copper oxidases with laccase properties have been reported. We provide the first evidence that the yellow laccase isolated from Sclerotinia sclerotiorum is obtained from a

BTK Inhibition Impairs the Innate Response Against Fungal Infection in Patients With Chronic Lymphocytic Leukemia.

Stefania Fiorcari et al.

Frontiers in immunology, 11, 2158-2158 (2020-09-29)

Infections represent a cause of morbidity and mortality in patients affected by chronic lymphocytic leukemia (CLL). Introduction of new drugs in CLL clinical practice has showed impressive efficacy, in particular those targeting BTK. Among the consistent clinical data, an increasing

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全球贸易项目编号

货号	GTIN
D9150-5G	04061833629673
D9150-1G	04061826690703

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