Merck
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文件

安全信息

D9302

Sigma-Aldrich

双醋瑞因

≥95% (HPLC)

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别名:
1,8-二乙酰氧基-3-羧基蒽醌
经验公式（希尔记法）:
C19H12O8
CAS号:
13739-02-1
分子量:
368.29
EC 号:
237-310-2
MDL编号:
MFCD00468030
PubChem化学物质编号:
24894281
NACRES:
NA.25

质量水平

200

检测方案

≥95% (HPLC)

形式

powder

SMILES字符串

CC(=O)Oc1cccc2C(=O)c3cc(cc(OC(C)=O)c3C(=O)c12)C(O)=O

InChI

1S/C19H12O8/c1-8(20)26-13-5-3-4-11-15(13)18(23)16-12(17(11)22)6-10(19(24)25)7-14(16)27-9(2)21/h3-7H,1-2H3,(H,24,25)

InChI key

TYNLGDBUJLVSMA-UHFFFAOYSA-N

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生化/生理作用

双醋瑞因是白介素-1B（IL-1B）产生的抑制剂。

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H315 - H319 - H335

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

法规信息

新产品

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示例

T1503
货号
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25G
包装规格/数量

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705578-5MG-PW

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1000309185

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. Can Product D9302, Diacerein, be dissolved in DMSO?

    Yes. Diacerein is soluble in DMSO at 1 mg/mL.  The compound is also soluble in acetic acid at a concentration of 25 mg in 8 mL, as stated on the specification sheet.

  6. What is the biological activity of Product D9302, Diacerein?

    Martindale, 30th ed. indicates that "Diacerein is a non-steroidal anti-inflammatory agent that has been used in musculoskeletal and joint disorders."  Diacerein acts by inhibiting interleukin-1. The chemicals encyclopedia published by the Royal Society of Chemistry, 11th ed., indicates that Diacerein "demonstrates anti-arthritic activity without inhibiting prostaglandin synthesis".

  7. What is the mechanism of action of Product D9302, Diacerein?

    "Diacerein is a slow acting symptomatic treatment of osteoarthritis which has demonstrated efficacy on functional manifestations of osteoarthritis and on the structural component. Two mechanisms of action have been validated: in vitro inhibition of interleukin-1 (IL-1) synthesis, the main cytokine involved in cartilage destruction, and activity on the synthesis of proteoglycans, and hyaluronic acid, the principal component of cartilage. Other studies presented here have provided further details concerning other mechanisms of action of diacerein", according to Presse Med., 33(9 Pt 2), S10-S12 (2004).

  8. What is the melting point of Product D9302, Diacerein?

    The chemicals encyclopedia published by the Royal Society of Chemistry (11th ed., entry #2939) reports a melting point of 217-218°C.

  9. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Vinícius Maria Gadotti et al.
Pharmacology, biochemistry, and behavior, 102(4), 549-554 (2012-07-04)
The present study evaluated the antinociceptive effect of the pro-inflammatory cytokines inhibitor diacerein in mice and its possible mechanism of action. The antinociception produced by diacerein was tested at different sites of action, moreover selective antagonists or agonists were used
E M Bartels et al.
Osteoarthritis and cartilage, 18(3), 289-296 (2009-10-28)
To estimate the efficacy and safety of diacerein as a pain-reducing agent in the treatment of osteoarthritis (OA), using meta-analysis of published randomized placebo-controlled trials (RCTs). Systematic searches of the bibliographic databases Medline, Embase, Cinahl, Chemical Abstracts, Cochrane and Web
Pascal Richette
Therapie, 66(5), 383-390 (2011-10-28)
According to international recommendations, acetaminophen should be used as a first-line therapy in patients with osteoarthritis, because of its safety and effectiveness. NSAIDs should be considered in patients unresponsive to acetaminophen, and should be prescribed at the lowest effective dose
The pathogenetic role of IL-1β in severe epidermolysis bullosa simplex.
Verena Wally et al.
The Journal of investigative dermatology, 133(7), 1901-1903 (2013-01-25)
P Härle et al.
Der Internist, 49(12), 1458-1462 (2008-11-18)
There is an increasing incidence in osteoarthritis, particularly following the 5th life-decade. However, also young people may suffer from severe osteoarthritis, which is estimated to be the most common cause of disability in adults resulting in substantial economic burden. To
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