跳转至内容
Merck
CN

E1151

Sigma-Aldrich

Anti-ERAB antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

别名:

Anti-Endoplasmic Reticulum-Associated Amyloid β-Peptide-Binding Protein

登录查看公司和协议定价

选择尺寸


关于此项目

MDL编号:
UNSPSC代码:
12352203
NACRES:
NA.41
技术服务
需要帮助?我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助
技术服务
需要帮助?我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助

生物来源

rabbit

质量水平

偶联物

unconjugated

抗体形式

affinity isolated antibody

抗体产品类型

primary antibodies

克隆

polyclonal

表单

buffered aqueous solution

分子量

antigen 27 kDa

种属反应性

human

包装

antibody small pack of 25 μg

技术

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1-2 μg/mL using human cerebellum tissue
western blot: 1-3 μg/mL using human SK-N-SH cells

UniProt登记号

运输

wet ice

储存温度

2-8°C

基因信息

human ... HSD17B10(3028)

一般描述

The gene HSD17B10 (hydroxysteroid (17-β) dehydrogenase 10) encodes 3-hydroxyacyl-CoA dehydrogenase type II, a member of the short-chain dehydrogenase/reductase superfamily.

免疫原

synthetic peptide corresponding to amino acids 100-116 of human ERAB protein.

应用

Anti-ERAB antibody produced in rabbit is suitable for immunohistochemistry at a working concentration of 1-2μg/mL using human cerebellum tissue with DAB detection and for immunoblotting at 1-3μg/mL using human neuroblastoma SK-N-SH cells with chemiluminescence detection.

生化/生理作用

By immunoblotting, the antibody detects native human ERAB. It does not react with mouse or rat.
The gene product is a subunit of mitochondrial ribonuclease P and plays a pivotal role in in mitochondrial tRNA maturation. It catalyzes the oxidation of a wide variety of fatty acids and steroids. The gene is linked to the neuronal dysfunction associated with Alzheimer disease (AD).

外形

Solution in 0.05 M sodium phosphate buffer, pH 7.5, containing 0.2% gelatin and 0.1% sodium azide

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

未找到合适的产品?  

试试我们的产品选型工具.

储存分类代码

10 - Combustible liquids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

法规信息

新产品
此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

没有发现合适的版本?

如果您需要特殊版本,可通过批号或批次号查找具体证书。

已有该产品?

在文件库中查找您最近购买产品的文档。

访问文档库

S D Yan et al.
Nature, 389(6652), 689-695 (1997-10-24)
Amyloid-beta is a neurotoxic peptide which is implicated in the pathogenesis of Alzheimer's disease. It binds an intracellular polypeptide known as ERAB, thought to be a hydroxysteroid dehydrogenase enzyme, which is expressed in normal tissues, but is overexpressed in neurons
Johann Holzmann et al.
Cell, 135(3), 462-474 (2008-11-06)
tRNAs are synthesized as immature precursors, and on their way to functional maturity, extra nucleotides at their 5' ends are removed by an endonuclease called RNase P. All RNase P enzymes characterized so far are composed of an RNA plus
Naeem Shafqat et al.
The Biochemical journal, 376(Pt 1), 49-60 (2003-08-15)
17beta-hydroxysteroid dehydrogenases (17beta-HSDs) catalyse the conversion of 17beta-OH (-hydroxy)/17-oxo groups of steroids, and are essential in mammalian hormone physiology. At present, eleven 17beta-HSD isoforms have been defined in mammals, with different tissue-expression and substrate-conversion patterns. We analysed 17beta-HSD type 10

我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系客户支持