E1157
Anti-Epidermal Growth Factor Receptor/Erb B1 antibody produced in goat
affinity isolated antibody, lyophilized powder
别名:
Anti-EGFR, Anti-ERBB, Anti-HER1, Anti-PIG61
生物来源
goat
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
lyophilized powder
种属反应性
human
技术
capture ELISA: 0.4 μg/mL
flow cytometry: 25 μg/mL
immunoprecipitation (IP): 1 μg/mL
western blot: 1-2 μg/mL
UniProt登记号
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... EGFR(1956)
相关类别
免疫原
purified, NSO cell-derived recombinant human epidermal growth factor receptor extracellular domain.
应用
Anti-Epidermal Growth Factor Receptor/Erb B1 antibody produced in goat was used for immunoblotting to analyze stable expression of anti-EGFR shRNA in MCF10A breast epithelial cell line.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunofluorescence (1 paper)
Immunofluorescence (1 paper)
生化/生理作用
EGFR is a transmembrane glycoprotein that binds to the EGF family. It is a pivotal regulator of cell proliferation, growth, differentiation and DNA repair after radiation-induced damage. Mutations in the gene encoding EGFR are associated with a number of malignancies including lung cancer and colorectal cancer.
外形
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
未找到合适的产品？
试试我们的产品选型工具.
储存分类代码
13 - Non Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
Fatimah Matalkah et al.
Breast cancer research : BCR, 18(1), 2-2 (2016-01-06)
Dysregulated receptor tyrosine kinase (RTK) signaling is a common occurrence in basal-like and triple-negative breast cancer (BTBC). As a result, RTK-targeting therapies have been initiated but proved difficult, mainly owing to the multiplicity of dysregulated RTKs. Hence, targeting master regulators
Xiangdong Zhou et al.
Cellular signalling, 24(1), 140-150 (2011-09-14)
Human epidermal growth factor receptor 2 (HER2) belongs to the EGFR family of receptor tyrosine kinases that comprises four members. As opposed to the other family members, HER2 does not require ligand binding for activation. Hence, HER2 molecules can undergo
Z Hartman et al.
Oncogene, 32(35), 4169-4180 (2012-10-03)
One of the causes of breast cancer is overexpression of the human epidermal growth factor receptor 2 (HER2). Enhanced receptor autophosphorylation and resistance to activation-induced downregulation have been suggested as mechanisms for HER2-induced sustained signaling and cell transformation. However, the
Thu H Truong et al.
Biochemistry, 51(50), 9954-9965 (2012-11-29)
Epidermal growth factor receptor (EGFR) exemplifies the family of receptor tyrosine kinases that mediate numerous cellular processes, including growth, proliferation, and differentiation. Moreover, gene amplification and EGFR mutations have been identified in a number of human malignancies, making this receptor
Jing Bai et al.
Asian Pacific journal of cancer prevention : APJCP, 13(10), 4879-4881 (2012-12-19)
Epidermal growth factor receptor (EGFR) overexpression is associated with resistance to chemotherapy and radiotherapy. The EGFR modulates DNA repair after radiation-induced damage through an association with the catalytic subunit of DNA protein kinase. DNA double-strand breaks (DSBs) are the most
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持