E4132
1,N6-Etheno-2′-deoxyadenosine
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C12H13N5O3
化学文摘社编号:
分子量:
275.26
UNSPSC Code:
41106305
PubChem Substance ID:
MDL number:
InChI
1S/C12H13N5O3/c18-4-8-7(19)3-9(20-8)17-6-14-10-11-13-1-2-16(11)5-15-12(10)17/h1-2,5-9,18-19H,3-4H2
SMILES string
OCC1OC(CC1O)n2cnc3c2ncn4ccnc34
InChI key
XQQIMTUYVDUWKJ-UHFFFAOYSA-N
form
solid
storage temp.
−20°C
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Deepak T Nair et al.
Nature structural & molecular biology, 13(7), 619-625 (2006-07-05)
The 1,N6-ethenodeoxyadenosine (epsilon dA) lesion is promutagenic and has been implicated in carcinogenesis. We show here that human Pol iota, a Y-family DNA polymerase, can promote replication through this lesion by proficiently incorporating a nucleotide opposite it. The structural basis
Andreas Brink et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 830(2), 255-261 (2005-11-22)
O(6)-Methyl-2'-deoxyguanosine (O(6)-mdGuo), 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodGuo), and 1,N(6)-etheno-2'-deoxyadenosine (epsilondAdo) are promutagenic DNA lesions originating from both endogenous and exogenous agents and actions (methylation, hydroxylation, lipid peroxidation products). A highly sensitive quantitative method was developed to measure these DNA adducts simultaneously, using liquid
Qingming Fang et al.
Mutation research, 624(1-2), 71-79 (2007-05-25)
Intake of linoleic acid (LA) increased etheno-DNA adducts induced by lipid peroxidation (LPO) in white blood cells (WBC) of female but not of male volunteers [J. Nair, C.E. Vaca, I. Velic, M. Mutanen, L.M. Valsta, H. Bartsch, High dietary omega-6
Poh-Gek Forkert et al.
Drug metabolism and disposition: the biological fate of chemicals, 35(5), 713-720 (2007-02-14)
Vinyl carbamate (VC) is derived from ethyl carbamate, a carcinogen formed in fermentation of food and alcoholic products. We have undertaken studies to test the hypothesis that an epoxide generated from VC oxidation leads to formation of 1,N6-ethenodeoxyadenosine (epsilon dAS).
Katya V Petrova et al.
Chemical research in toxicology, 20(11), 1685-1692 (2007-10-03)
Background levels of etheno adducts have been attributed to the reaction of DNA with 2,3-epoxyaldehydes, a proposed product of lipid peroxidation. We have examined the reaction of (2R,3S)-epoxyhexanal with dGuo to give 7-(1S-hydroxybutyl)-1,N(2)-etheno-dGuo. We observed that the stereochemistry of the
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持