生物来源
goat
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
lyophilized powder
种属反应性
mouse
技术
indirect ELISA: 0.5-1.0 μg/mL
western blot: 0.1-0.2 μg/mL
UniProt登记号
储存温度
−20°C
基因信息
mouse ... Epha4(13838)
一般描述
By immunoblotting and ELISA, the antibody shows ~10% cross-reactivity with recombinant human ephrin-A5 and <5% cross-reactivity with recombinant human EphA1, mouse EphA2, mouse EphA3, rat EphA5, mouse EphA6, mouse EphA7, and mouse EphA8.
免疫原
recombinant mouse EphA4, extracellular domain, expressed in NSO cells.
生化/生理作用
EPH receptor A4 is a protein-tyrosine kinase family that belongs to the ephrin receptor subfamily. It binds the ephrin-A and ephrin-B ligands and regulates developmental events, particularly those of the nervous system. EphA4 regulates the axonal growth, astrocyte reactivity and neuroinflammation in experimental autoimmune encephalomyelitis. High expression of EphA4 correlates with tumor progression, invasion and metastasis of gastric cancer and is a suitable prognostic marker.
外形
Lyophilized from 0.2 μm filtered solution in phosphate buffered saline.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Bin Shen et al.
Neuropsychiatric disease and treatment, 17, 1667-1678 (2021-06-04)
The aim of our study was to explore the role of long non-coding RNA (lncRNA) growth arrest-specific 5 (GAS5) in ischemic stroke using oxygen-glucose deprivation/reperfusion (OGD/R)-induced bEnd.3 cells as in vitro cell model. Real-time quantitative polymerase chain reaction (RT-qPCR) and
Kohji Miyazaki et al.
BMC clinical pathology, 13(1), 19-19 (2013-06-07)
Erythropoietin-producing hepatocellular (Eph) receptor, consisting of a family of receptor tyrosine kinases, plays critical roles in tumour development and is considered an attractive target for cancer therapy. Tumour samples were obtained from 222 patients with gastric adenocarcinoma who underwent gastrectomy.
Manish Tandon et al.
Expert opinion on therapeutic targets, 15(1), 31-51 (2010-12-15)
High mortality rates with cancers warrant further development of earlier diagnostics and better treatment strategies. Membrane-bound erythropoietin-producing hepatocellular receptor tyrosine kinase class A2 (EphA2) is overexpressed in breast, prostate, urinary bladder, skin, lung, ovary and brain cancers. EphA2 overexpression in
Kathryn M Munro et al.
PloS one, 8(2), e55948-e55948 (2013-02-08)
The EphA4 receptor tyrosine kinase is a major regulator of axonal growth and astrocyte reactivity and is a possible inflammatory mediator. Given that multiple sclerosis (MS) is primarily an inflammatory demyelinating disease and in mouse models of MS, such as
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