E7019
Exendin-3
≥97%
Amino Acid Sequence
His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2
一般描述
Exendin-3 is a pancreatic secretagogue, which is a member of the glucagon family. It is found in the venom of Heloderma horridurn, which is a Gila monster lizard. It has a molecular mass of 4200Da and is composed of 39 amino acids. 12 amino-acids region in its N-terminal is highly homologous to secretin. Its C-terminal contains an amide group.
应用
Exendin-3 has been used to assess its effect in glucagon receptor knockout mice (Gcgr-/-) and wild-type mice, on glucose-stimulated insulin secretion.
其他说明
Originally isolated from Heloderma horridum (Gila monster lizard) venom.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Actions of Helodermatidae venom peptides and mammalian glucagon-like peptides on gastric chief cells.
Rai, A., et al.
The American Journal of Physiology, 265 (1993)
Bioactive peptides from lizard venoms.
J P Raufman
Regulatory peptides, 61(1), 1-18 (1996-01-16)
J Eng et al.
The Journal of biological chemistry, 265(33), 20259-20262 (1990-11-25)
An amino-terminal histidyl structure (His1) is characteristic of most peptides in the glucagon superfamily. An assay for His1 peptides performed by amino-terminal amino acid sequencing was used to screen venom from the Gila monster lizard, Heloderma horridum. Two His1 peptides
S A Beak et al.
The Journal of clinical investigation, 101(6), 1334-1341 (1998-04-29)
To examine the influence of the putative satiety factor (GLP-1) on the hypothalamo-pituitary-gonadal axis, we used GT1-7 cells as a model of neuronal luteinizing hormone- releasing hormone (LHRH) release. GLP-1 caused a concentration-dependent increase in LHRH release from GT1-7 cells.
Heidi Sørensen et al.
Diabetes, 55(12), 3463-3469 (2006-11-30)
In previous studies, glucagon receptor knockout mice (Gcgr(-/-)) display reduced blood glucose and increased glucose tolerance, with hyperglucagonemia and increased levels of glucagon-like peptide (GLP)-1. However, the role of glucagon receptor signaling for the regulation of islet function and insulin
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