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E9156

Encainide 盐酸盐

Name: Encainide 盐酸盐
Brand: SIGMA

≥98% (HPLC), powder

别名:

(+/-)-4-Methoxy-N-[2-[2-(1-methyl-2-piperidinyl)ethyl]phenyl]benzamide 盐酸盐, MJ-9067

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关于此项目

经验公式（希尔记法）:

C₂₂H₂₈N₂O₂ · HCl

化学文摘社编号:

66794-74-9

分子量:

388.93

NACRES:

NA.77

PubChem Substance ID:

329799083

UNSPSC Code:

12352200

MDL number:

MFCD01667688

Assay:

≥98% (HPLC)

Form:

powder

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属性

assay

≥98% (HPLC)

form

powder

solubility

H₂O: >25 mg/mL

originator

Bristol-Myers Squibb

storage temp.

2-8°C

SMILES string

Cl.COc1ccc(cc1)C(=O)Nc2ccccc2CCC3CCCCN3C

InChI

1S/C22H28N2O2.ClH/c1-24-16-6-5-8-19(24)13-10-17-7-3-4-9-21(17)23-22(25)18-11-14-20(26-2)15-12-18;/h3-4,7,9,11-12,14-15,19H,5-6,8,10,13,16H2,1-2H3,(H,23,25);1H

InChI key

OJIIZIWOLTYOBS-UHFFFAOYSA-N

Gene Information

human ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)

说明

Biochem/physiol Actions

Encainide hydrochloride is a sodium channel blocker and class Ic antiarrhythmic.

Encainide hydrochloride is a sodium channel blocker and class Ic antiarrhythmic. Encainide is a non-chiral antiarrhythmic and benzanilide derivative.

Features and Benefits

This compound was developed by Bristol-Myers Squibb. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

GHS06

signalword

Danger

hcodes

H301,H315,H319,H335

pcodes

P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

018K46111

018K4611

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商品

Sodium Channels

Voltage-gated sodium channels are present in most excitable cell membranes and play an important role in generating action potentials.

钠通道

电压门控钠通道存在于大多数可兴奋细胞膜中，在产生动作电位方面起着重要作用。

Effects of flecainide, encainide, and clofilium on ventricular refractory period extension by transcardiac shocks.

R J Sweeney et al.

Pacing and clinical electrophysiology : PACE, 19(1), 50-60 (1996-01-01)

The mechanisms by which pharmacological agents alter electrical defibrillation are not fully understood. It has been proposed that, in addition to directly stimulating tissue, defibrillation may involve refractory period extension (RPE) produced by the shock. Accordingly, pharmacological agents might modulate

Developmental electrophysiology of encainide and its major metabolites on the Purkinje fiber action potential.

C L Case et al.

Biology of the neonate, 66(6), 330-338 (1994-01-01)

With clinical data suggesting that neonates may be more prone to developing electrophysiologic side effects from encainide, this study investigates the in vitro developmental electrophysiologic effects of encainide and its major metabolites on the action potential parameters of the canine

ST segment elevation induced by class IC antiarrhythmic agents: underlying electrophysiologic mechanisms and insights into drug-induced proarrhythmia.

S C Krishnan et al.

Journal of cardiovascular electrophysiology, 9(11), 1167-1172 (1998-12-03)

Three patients in whom Class IC sodium channel blockers induced ST segment elevation in leads V1 through V3 are described. The underlying electrophysiologic mechanism, implications for drug-induced proarrhythmia, and the relationship of the finding to the Brugada syndrome type of

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全球贸易项目编号

货号	GTIN
E9156-50MG	04061832574455
E9156-10MG	04061832574448