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Merck
CN

E9156

Sigma-Aldrich

Encainide 盐酸盐

≥98% (HPLC), powder

别名:

(+/-)-4-Methoxy-N-[2-[2-(1-methyl-2-piperidinyl)ethyl]phenyl]benzamide 盐酸盐, MJ-9067

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关于此项目

经验公式（希尔记法）:
C22H28N2O2 · HCl
化学文摘社编号:
66794-74-9
分子量:
388.93
MDL编号:
MFCD01667688
UNSPSC代码:
12352200
PubChem化学物质编号:
329799083
NACRES:
NA.77

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方案

≥98% (HPLC)

表单

powder

溶解性

H2O: >25 mg/mL

创始人

Bristol-Myers Squibb

储存温度

2-8°C

SMILES字符串

Cl.COc1ccc(cc1)C(=O)Nc2ccccc2CCC3CCCCN3C

InChI

1S/C22H28N2O2.ClH/c1-24-16-6-5-8-19(24)13-10-17-7-3-4-9-21(17)23-22(25)18-11-14-20(26-2)15-12-18;/h3-4,7,9,11-12,14-15,19H,5-6,8,10,13,16H2,1-2H3,(H,23,25);1H

InChI key

OJIIZIWOLTYOBS-UHFFFAOYSA-N

基因信息

human ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)

生化/生理作用

Encainide hydrochloride is a sodium channel blocker and class Ic antiarrhythmic.
Encainide hydrochloride is a sodium channel blocker and class Ic antiarrhythmic. Encainide is a non-chiral antiarrhythmic and benzanilide derivative.

特点和优势

This compound was developed by Bristol-Myers Squibb. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险分类

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
018K46111
018K4611

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J E Tisdale et al.
Journal of clinical pharmacology, 33(7), 623-630 (1993-07-01)
The efficacy of class 1C antiarrhythmic agents was determined in 36 patients with inducible sustained monomorphic ventricular tachycardia during baseline electrophysiology study (EPS), who continued to have inducible monomorphic ventricular tachycardia during EPS on class 1A antiarrhythmic therapy. Of 12
A E Epstein et al.
JAMA, 270(20), 2451-2455 (1993-11-24)
To test the hypothesis that in survivors of myocardial infarction, the suppression of ventricular premature depolarizations improves survival free of cardiac arrest and arrhythmic death. International, prospective, multicenter, randomized, placebo-controlled trial. University and community hospitals. A total of 3549 patients
S Goldstein et al.
Circulation, 91(1), 79-83 (1995-01-01)
We tested the hypothesis that patients whose ventricular arrhythmias are easy to suppress have a lower rate of arrhythmic death, defined as arrhythmic death and nonfatal cardiac arrest, the primary end point in the Cardiac Arrhythmia Suppression Trials (CAST-I and
S C Krishnan et al.
Journal of cardiovascular electrophysiology, 9(11), 1167-1172 (1998-12-03)
Three patients in whom Class IC sodium channel blockers induced ST segment elevation in leads V1 through V3 are described. The underlying electrophysiologic mechanism, implications for drug-induced proarrhythmia, and the relationship of the finding to the Brugada syndrome type of
A Hallstrom et al.
Journal of the American College of Cardiology, 25(6), 1250-1257 (1995-05-01)
We studied the relations between heart failure, ejection fraction, arrhythmia suppression and mortality. Both left ventricular ejection fraction and functional class of heart failure are strongly associated with mortality after acute myocardial infarction. Both are also related to the presence
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钠通道

电压门控钠通道存在于大多数可兴奋细胞膜中，在产生动作电位方面起着重要作用。

Sodium Channels

Voltage-gated sodium channels are present in most excitable cell membranes and play an important role in generating action potentials.

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