E9654
S1P4 C-Terminal Blocking Peptide
~1 mg/mL, buffered aqueous solution
别名:
EDG-6, Endothelial Cell Differentiation Gene 6
form
buffered aqueous solution
mol wt
~2.5 kDa
concentration
~1 mg/mL
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Quality Level
Gene Information
human ... S1PR4(8698)
General description
S1PR4 (sphingosine-1-phosphate receptor 4) is a member of the S1P or the Edg (endothelial differentiation gene) receptor family, which contains five members. It is a G-protein coupled receptor (GPCR). Its 3rd transmembrane domain contains a conserved glutamic acid residue. It is expressed in lung, hematopoietic and lymphoid tissue. This gene is localized to human chromosome 19p13.3.
Biochem/physiol Actions
G protein-coupled receptor whose ligand might be a lysophospholipid or lysosphingo-lipid. Specifically expressed in fetal and adult lymphoid, hematopoietic and lung tissue.
S1PR4 (sphingosine-1-phosphate receptor 4) functions as a receptor for S1P, which is a phospholipid growth factor, and might control the transport of dendritic cells (DCs). Thus, it might promote Th2 lymphocyte-mediated immunity. S1P4 mediates RAS(rat sarcoma)-MAPK (mitogen-activated protein kinase) pathway by interacting with Gi/o proteins. In ER (estrogen receptor)- breast cancer, its elevated expression is linked with decreased overall survival as well as disease-free survival.
Physical form
Solution in phosphate buffered saline, pH 7.3.
Analysis Note
Used as a blocking peptide in immunoblotting applications with Anti-S1P4 polyclonal and monoclonal antibodies (Prod. Nos. E 7653, E 9529).
flash_point_f
Not applicable
flash_point_c
Not applicable
wgk
WGK 1
存储类别
12 - Non Combustible Liquids
法规信息
新产品
此项目有
Marco Idzko et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 16(6), 625-627 (2002-03-29)
Sphingosine 1-phosphate (S1P) is a potent extracellular lysolipid phosphoric acid mediator that is released after IgE-stimulation of mast cells. Here we investigated the biological activity and intracellular signaling of S1P on human dendritic cells (DC), which are specialized antigen presenting
Gill Holdsworth et al.
BMC biochemistry, 5, 12-12 (2004-08-10)
Sphingosine-1-phosphate and lysophosphatidic acid (LPA) are ligands for two related families of G protein-coupled receptors, the S1P and LPA receptors, respectively. The lysophospholipid ligands of these receptors are structurally similar, however recognition of these lipids by these receptors is highly
James J A Contos et al.
FEBS letters, 531(1), 99-102 (2002-10-29)
A genomic analysis of the s1p(4)/lp(C1)/Edg6 mouse sphingosine-1-phosphate (S1P) G protein-coupled receptor gene revealed it to be located on central chromosome 10 and to consist of two exons with an intronless coding region. Surprisingly, we found the gene encoding the
M H Gräler et al.
Genomics, 53(2), 164-169 (1998-10-29)
EDG receptors constitute a novel subfamily of G-protein-coupled receptors displaying a heterogeneous expression pattern. It was shown recently that the four members of this family thus far identified can bind lysophospholipids or lysosphingolipids as ligands. Here we report the identification
J Ohotski et al.
British journal of cancer, 106(8), 1453-1459 (2012-03-31)
We previously reported that sphingosine 1-phosphate receptor 4 (S1P(4)) is expressed and stimulates the ERK-1/2 pathway via a human epidermal growth factor receptor 2 (HER2)-dependent mechanism in oestrogen receptor-negative (ER(-)) MDA-MB-453 breast cancer cells. Clinical relevance of S1P(4) and sphingosine
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