表单
buffered aqueous solution
质量水平
分子量
~2.5 kDa
浓度
~1 mg/mL
UniProt登记号
运输
wet ice
储存温度
−20°C
基因信息
human ... S1PR4(8698)
一般描述
S1PR4 (sphingosine-1-phosphate receptor 4) is a member of the S1P or the Edg (endothelial differentiation gene) receptor family, which contains five members. It is a G-protein coupled receptor (GPCR). Its 3rd transmembrane domain contains a conserved glutamic acid residue. It is expressed in lung, hematopoietic and lymphoid tissue. This gene is localized to human chromosome 19p13.3.
生化/生理作用
G protein-coupled receptor whose ligand might be a lysophospholipid or lysosphingo-lipid. Specifically expressed in fetal and adult lymphoid, hematopoietic and lung tissue.
S1PR4 (sphingosine-1-phosphate receptor 4) functions as a receptor for S1P, which is a phospholipid growth factor, and might control the transport of dendritic cells (DCs). Thus, it might promote Th2 lymphocyte-mediated immunity. S1P4 mediates RAS(rat sarcoma)-MAPK (mitogen-activated protein kinase) pathway by interacting with Gi/o proteins. In ER (estrogen receptor)- breast cancer, its elevated expression is linked with decreased overall survival as well as disease-free survival.
外形
Solution in phosphate buffered saline, pH 7.3.
分析说明
Used as a blocking peptide in immunoblotting applications with Anti-S1P4 polyclonal and monoclonal antibodies (Prod. Nos. E 7653, E 9529).
储存分类代码
10 - Combustible liquids
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
M H Gräler et al.
Genomics, 53(2), 164-169 (1998-10-29)
EDG receptors constitute a novel subfamily of G-protein-coupled receptors displaying a heterogeneous expression pattern. It was shown recently that the four members of this family thus far identified can bind lysophospholipids or lysosphingolipids as ligands. Here we report the identification
Marco Idzko et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 16(6), 625-627 (2002-03-29)
Sphingosine 1-phosphate (S1P) is a potent extracellular lysolipid phosphoric acid mediator that is released after IgE-stimulation of mast cells. Here we investigated the biological activity and intracellular signaling of S1P on human dendritic cells (DC), which are specialized antigen presenting
Gill Holdsworth et al.
BMC biochemistry, 5, 12-12 (2004-08-10)
Sphingosine-1-phosphate and lysophosphatidic acid (LPA) are ligands for two related families of G protein-coupled receptors, the S1P and LPA receptors, respectively. The lysophospholipid ligands of these receptors are structurally similar, however recognition of these lipids by these receptors is highly
James J A Contos et al.
FEBS letters, 531(1), 99-102 (2002-10-29)
A genomic analysis of the s1p(4)/lp(C1)/Edg6 mouse sphingosine-1-phosphate (S1P) G protein-coupled receptor gene revealed it to be located on central chromosome 10 and to consist of two exons with an intronless coding region. Surprisingly, we found the gene encoding the
J Ohotski et al.
British journal of cancer, 106(8), 1453-1459 (2012-03-31)
We previously reported that sphingosine 1-phosphate receptor 4 (S1P(4)) is expressed and stimulates the ERK-1/2 pathway via a human epidermal growth factor receptor 2 (HER2)-dependent mechanism in oestrogen receptor-negative (ER(-)) MDA-MB-453 breast cancer cells. Clinical relevance of S1P(4) and sphingosine
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持