F0393
2′-Fucosyl-D-lactose
from human milk, ≥98% (HPAE/PAD)
别名:
α-L-Fuc-(1→2)-β-D-Gal-(1→4)-D-Glc
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关于此项目
经验公式（希尔记法）:
C18H32O15
化学文摘社编号:
分子量:
488.44
UNSPSC Code:
12352201
PubChem Substance ID:
MDL number:
InChI
1S/C18H32O15/c1-4-7(21)9(23)13(27)17(29-4)33-15-10(24)8(22)5(2-19)31-18(15)32-14-6(3-20)30-16(28)12(26)11(14)25/h4-28H,2-3H2,1H3/t4-,5+,6+,7+,8-,9+,10-,11+,12+,13-,14+,15+,16?,17+,18-/m0/s1
SMILES string
C[C@@H]1O[C@H](O[C@@H]2[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]2O[C@H]3[C@H](O)[C@@H](O)C(O)O[C@@H]3CO)[C@@H](O)[C@H](O)[C@@H]1O
InChI key
SNFSYLYCDAVZGP-ZTFPOLCTSA-N
biological source
human milk
assay
≥98% (HPAE/PAD)
form
powder
solubility
H2O: 2 mg + 0.2 mL, clear, colorless
storage temp.
2-8°C
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Application
2′-Fucosyl-D-lactose is used as substrate to identify, differentiate and characterize fucosidases. It is also used in the development of biosensors to identify anti-infective oligosaccharides. 2′-Fucosyl-D-lactose is used to differentiate IL-8 receptor specificity and function. It may be used to study is effects on intestinal microbiota and as a reference compound in assays developed to detect and measure milk sugars.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
涉药品监管产品
此项目有
Myriam Coulet et al.
Regulatory toxicology and pharmacology : RTP, 68(1), 59-69 (2013-11-23)
In order to match the composition of human breast milk more closely, it is now possible to supplement commercial infant formula (IF) with synthesised oligosaccharides that are chemically identical to human milk oligosaccharides. The safety data generated on a new
Zhuo-Teng Yu et al.
Glycobiology, 23(2), 169-177 (2012-10-03)
Breast-fed infant microbiota is typically rich in bifidobacteria. Herein, major human milk oligosaccharides (HMOS) are assessed for their ability to promote the growth of bifidobacteria and to acidify their environment, key features of prebiotics. During in vitro anaerobic fermentation of
C Campbell et al.
Cell, 35(1), 303-309 (1983-11-01)
Two rare and dominant mutants of Chinese hamster ovary (CHO) cells, LEC11 and LEC12, express the mouse embryonic antigen SSEA-1. Parental CHO cells and the revertants, LEC11.R9 and LEC12.R10, do not express this antigen as detected by a sensitive radioimmunoassay
M Krug et al.
Brain research, 643(1-2), 130-135 (1994-04-18)
Male Wistar rats were intrahippocampally injected with L-fucose and the sugar epitope 2'-fucosyl-lactose prior to induction of long-term potentiation (LTP). Both substances had only a minimal and short-lasting depressive effect on the monosynaptically evoked field potential recorded in the dorsal
Jonathan A Lane et al.
Analytical biochemistry, 410(2), 200-205 (2010-11-30)
It is now well accepted that milk oligosaccharides can have a direct inhibitory effect on pathogenic microorganisms by interfering with their adhesion to human cells. Many free oligosaccharides from milk are considered to be soluble receptor analogs of epithelial cell
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