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Merck
CN

F0503

5-氟-2′-脱氧尿嘧啶核苷

thymidylate synthase inhibitor

别名:

2′-脱氧-5-氟脲苷, FUDR, 氟脲苷

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关于此项目

经验公式(希尔记法):
C9H11FN2O5
化学文摘社编号:
分子量:
246.19
NACRES:
NA.77
PubChem Substance ID:
EC Number:
200-072-5
Beilstein/REAXYS Number:
90221
MDL number:
UNSPSC Code:
12352208
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biological source

synthetic (organic)

Quality Level

assay

≥99% (HPLC)

form

powder

mp

148 °C (lit.)

solubility

water: 50 mg/mL, clear, colorless to faintly yellow

storage temp.

room temp

SMILES string

OC[C@H]1O[C@H](C[C@@H]1O)N2C=C(F)C(=O)NC2=O

InChI

1S/C9H11FN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1

InChI key

ODKNJVUHOIMIIZ-RRKCRQDMSA-N

Gene Information

human ... TYMS(7298)
mouse ... Tyms(22171)

General description

5-氟-2′-脱氧脲核苷,也称为氟脲苷,可在癌细胞中引起DNA介导的细胞毒性作用。氟脲苷可有效治疗肝癌 并且能够清除金黄色葡萄球菌( Staphylococcus aureus)的毒性。氟脲苷与吉西他滨的二肽前药组合具有更强的细胞渗透性和抗增殖活性。氟脲苷能够有效治疗实体瘤和晚期癌症。

Application

5-氟-2′-脱氧脲核苷已被用作施旺(schwann)细胞增殖、胶质细胞增殖 和背根神经节培养物中非神经细胞的有丝分裂抑制剂。

Biochem/physiol Actions

一种抗肿瘤药物,是胸苷酸合成酶的有效抑制剂 通过低水平支原体感染,可使癌细胞培养物产生FUdR耐受性。


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pictograms

Skull and crossbones

signalword

Danger

hcodes

Hazard Classifications

Acute Tox. 3 Oral

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves



历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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全球贸易项目编号

货号GTIN
F0503-1G04061833611227
F0503-250MG04061833611234
F0503-100MG04061833611203