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F0778

Felbamate

NMDA glutamate receptor antagonist

别名:

2-Phenyl-1,3-propanediol dicarbamate

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关于此项目

经验公式（希尔记法）:
C11H14N2O4
化学文摘社编号:
25451-15-4
分子量:
238.24
NACRES:
NA.77
PubChem Substance ID:
24277968
UNSPSC Code:
12352200
EC Number:
247-001-4
MDL number:
MFCD00865296
Quality level:
200
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产品名称

Felbamate,

Quality Level

200

solubility

alcohol: soluble

SMILES string

NC(=O)OCC(COC(N)=O)c1ccccc1

InChI

1S/C11H14N2O4/c12-10(14)16-6-9(7-17-11(13)15)8-4-2-1-3-5-8/h1-5,9H,6-7H2,(H2,12,14)(H2,13,15)

InChI key

WKGXYQFOCVYPAC-UHFFFAOYSA-N

Gene Information

human ... GRIN1(2902), GRIN2A(2903), GRIN2B(2904), GRIN2C(2905), GRIN2D(2906), GRIN3A(116443), GRIN3B(116444)

Biochem/physiol Actions

Anticonvulsant agent that is an allosteric antagonist at the NR2B subunit of the NMDA glutamate receptor; also has γ-aminobutyric acid (GABAA) receptor agonist properties.

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存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000216194
0000536650
0000536651
0000211844
0000216194

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相关内容

Huai-Ren Chang et al.
Journal of medicinal chemistry, 51(6), 1534-1545 (2008-03-04)
The antiepileptic effect of felbamate (FBM) is ascribable to gating modification of NMDA receptors. Using site-directed mutagenesis and electrophysiological studies, we found that single-point mutations of four pairs of homologous residues in the external vestibule of the receptor pore, namely
J M Rho et al.
The Journal of pharmacology and experimental therapeutics, 280(3), 1383-1391 (1997-03-01)
Felbamate and meprobamate are structurally related propanediol dicarbamates that possess distinct pharmacological profiles. Felbamate is a minimally sedative, broad-spectrum anticonvulsant, whereas meprobamate is a strong sedative-anxiolytic agent. Previously, we reported that felbamate potentiates gamma-aminobutyric acid(A) (GABA(A)) receptor Cl- currents and
W M Brown et al.
Critical reviews in neurobiology, 12(3), 205-222 (1998-12-10)
Felbamate was launched in 1993 in the U.S. as a "new generation" antiepileptic drug (AED) with a unique mechanism of action. It proved efficacious in patients refractory to other AEDs and was particularly beneficial in children suffering from Lennox-Gastaut syndrome
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全球贸易项目编号

货号GTIN
F0778-50MG04061832556512
F0778-10MG04061833611401