F124
Furafylline
≥98% (HPLC), powder, caffeine inhibitor
别名:
3-(2-Furanylmethyl)-3,7-dihydro-1,8-dimethyl-1H-purine-2,6-dione
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关于此项目
经验公式（希尔记法）:
C12H12N4O3
化学文摘社编号:
分子量:
260.25
MDL编号:
UNSPSC代码:
41106305
PubChem化学物质编号:
NACRES:
NA.77
产品名称
Furafylline, ≥98% (HPLC)
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
mp
274-275 °C
溶解性
DMSO: 10 mg/mL, clear
储存温度
room temp
SMILES字符串
CN1C(=O)N(Cc2ccco2)c3nc(C)[nH]c3C1=O
InChI
1S/C12H12N4O3/c1-7-13-9-10(14-7)16(6-8-4-3-5-19-8)12(18)15(2)11(9)17/h3-5H,6H2,1-2H3,(H,13,14)
InChI key
KGQZGCIVHYLPBH-UHFFFAOYSA-N
基因信息
human ... CYP1A2(1544)
生化/生理作用
Furafylline (1,8-dimethyl-3-(2′ -furfuryl)methylxanthine) is a xanthine derivative. It is preferred in treating asthma. It serves as a N3-demethylation inhibitor of caffeine. Furafylline does not show much effect on human monooxygenase activities. It is considered as an efficient bronchodilator and as an inhibitor of anaphylactic reactions, when compared to theophylline.
Furafylline is a methyl xanthine derivative with longer duration of action than theophylline and an inhibitor of cytochrome P4501A2.
特点和优势
This compound is a featured product for ADME Tox and Cyclic Nucleotide research. Discover more featured ADME Tox and Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
涉药品监管产品
此项目有
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D Sesardic et al.
British journal of clinical pharmacology, 29(6), 651-663 (1990-06-01)
1. Furafylline (1,8-dimethyl-3-(2'-furfuryl)methylxanthine) is a methylxanthine derivative that was introduced as a long-acting replacement for theophylline in the treatment of asthma. Administration of furafylline was associated with an elevation in plasma levels of caffeine, due to inhibition of caffeine oxidation
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Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
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