F2552
福美斯坦
solid
别名:
4-Hydroxyandrost-4-ene-3,17-dione, CGP-32349
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关于此项目
经验公式（希尔记法）:
C19H26O3
化学文摘社编号:
分子量:
302.41
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352204
MDL number:
产品名称
福美斯坦, solid
InChI key
OSVMTWJCGUFAOD-KZQROQTASA-N
SMILES string
C[C@]12CC[C@H]3[C@@H](CCC4=C(O)C(=O)CC[C@]34C)[C@@H]1CCC2=O
InChI
1S/C19H26O3/c1-18-10-8-15(20)17(22)14(18)4-3-11-12-5-6-16(21)19(12,2)9-7-13(11)18/h11-13,22H,3-10H2,1-2H3/t11-,12-,13-,18+,19-/m0/s1
biological source
synthetic (organic)
assay
≥98% (HPLC)
form
solid
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
solubility
chloroform: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow
application(s)
forensics and toxicology
veterinary
storage temp.
2-8°C
Quality Level
Gene Information
human ... CYP19A1(1588)
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Biochem/physiol Actions
Aromatase inhibitor used as an anti-cancer agent against estrogen-dependent tumors.
signalword
Danger
hcodes
Hazard Classifications
Repr. 1B
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
监管及禁止进口产品
此项目有
Davide Mauri et al.
Journal of the National Cancer Institute, 98(18), 1285-1291 (2006-09-21)
Aromatase inhibitors and inactivators have been extensively tested in patients with advanced breast cancer, but it is unclear whether they offer any survival benefits compared with standard hormonal treatment with tamoxifen or progestagens. We performed a meta-analysis of randomized controlled
P E Lønning et al.
The Journal of steroid biochemistry and molecular biology, 77(1), 39-47 (2001-05-19)
Formestane (Lentaron(R), 4-hydroxyandrostenedione) is a steroidal aromatase inhibitor used for treatment of advanced breast cancer. Clinically, it is administered as a depot form once fortnightly by intramuscular (i.m.) injection. To investigate the pharmacokinetics, bioavailability and metabolism of the drug, seven
P E Lønning
Breast cancer research and treatment, 49 Suppl 1, S45-S52 (1998-10-31)
Steroidal aromatase inhibitors like formestane and exemestane are useful drugs for endocrine treatment of postmenopausal breast cancer. In addition, these drugs should be considered valuable probes to explore the biology of breast cancer with particular emphasis on possible relations between
Ichiro Sakata et al.
The Journal of endocrinology, 190(3), 749-757 (2006-09-28)
Ghrelin, an endogenous ligand for the GH secretagogue receptor, is predominantly produced in the stomach. Little is known about the regulation mechanism of gastric ghrelin. Here, we report that estrogen synthesized in the stomach induces rat gastric ghrelin gene expression
Aaron T Wright et al.
Journal of the American Chemical Society, 131(30), 10692-10700 (2009-07-09)
Cytochrome P450 (P450) enzymes regulate a variety of endogenous signaling molecules and play central roles in the metabolism of xenobiotics and drugs. We recently showed that an aryl alkyne serves as an effective activity-based probe for profiling mouse liver microsomal
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