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Merck
CN

F3803

Monoclonal Anti-Follicular Dendritic Cells (FDC) antibody produced in mouse

clone CNA.42, tissue culture supernatant

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关于此项目

UNSPSC Code:
12352203
MDL number:
Conjugate:
unconjugated
Clone:
CNA.42, monoclonal
Application:
IHC (f), IHC (p)
Citations:
6
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conjugate

unconjugated

biological source

mouse

antibody form

tissue culture supernatant

antibody product type

primary antibodies

clone

CNA.42, monoclonal

species reactivity

human

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:50 using human tonsil, immunohistochemistry (frozen sections): 1:25-1:50 using acetone-fixed, cryostat sections of human tonsil

shipped in

wet ice

storage temp.

2-8°C

target post-translational modification

unmodified

Quality Level

Immunogen

mouse CEM T cell line.

Application

Monoclonal Anti-Follicular Dendritic Cells (FDC) antibody is suitable for immunohistochemistry studies of formalin-fixed, paraffin-embedded sections at a dilution of 1:25-1:50 using human tonsil and frozen sections at a dilution of 1:25-1:50 using acetone-fixed, cryostat sections of human tonsil.

Biochem/physiol Actions

Follicular dendritic cells (FDCs) are phenotypically distinct cells that are restricted to primary and secondary follicles of any secondary lymphoid organs, lymphoid dendritic cells are found in T cell-rich interfollicular areas. FDCs are morphologically large cells (often containing multiple nuclei) that exhibit numerous dendritic processes. Initially, FDCs are characterized as ′accessory′ cells that passively support germinal centre (GC) responses. However, latter it has been postulated that FDCs actively shape humoral immunity.

Physical form

Tissue culture supernatant (culture medium with fetal calf serum), containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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存储类别

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

新产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Eirini Moysi et al.
Frontiers in immunology, 12, 683396-683396 (2021-06-29)
CD4 T cells are key mediators of adaptive immune responses during infection and vaccination. Within secondary lymphoid organs, helper CD4 T cells, particularly those residing in germinal centers known as follicular helper T cells (Tfh), provide critical help to B-cells
Kirsten van Nierop et al.
Seminars in immunology, 14(4), 251-257 (2002-08-07)
Follicular dendritic cells (FDCs) have important functions in the selection of memory B lymphocytes during germinal center reactions (GCR). They present native antigens to potential memory cells, of which only B cells with high affinity B cell receptors (BCR) can
Lili Wang et al.
Human gene therapy, 22(11), 1389-1401 (2011-04-12)
Vectors based on the primate-derived adeno-associated virus serotype 8 (AAV8) are being evaluated in preclinical and clinical models. Natural infections with related AAVs activate memory B cells that produce antibodies capable of modulating the efficacy and safety of the vector.
S Petrasch et al.
British journal of haematology, 80(1), 21-26 (1992-01-01)
Follicular dendritic cells (FDC) are located within the B-cell follicles of non-malignant lymphatic tissues and within non-Hodgkin-lymphomas (NHL) derived from the germinal centre or the mantlezone. The interactions between FDC and non-neoplastic B-cells have been extensively investigated but so far
Balthasar A Heesters et al.
Nature reviews. Immunology, 14(7), 495-504 (2014-06-21)
Follicular dendritic cells (FDCs) are essential for high-affinity antibody production and for the development of B cell memory. Historically, FDCs have been characterized as 'accessory' cells that passively support germinal centre (GC) responses. However, recent observations suggest that FDCs actively

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