生物来源
human plasma
表单
powder
质量
≥60% of protein is clottable
分子量
α-chain 63.5 kDa
β-chain 56 kDa
γ chain 47 kDa (about 4% carbohydrate content)
soluble dimer 340 kDa
浓度
55-75% protein (biuret)
55-75% protein
溶解性
0.9% NaCl: soluble 10 mg/mL
储存温度
−20°C
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一般描述
Fibrinogen, or Factor I, is a blood protein that is involved in clotting and is converted to fibrin by thrombin. Fibrinogen has an approximate molecular weight of 340 kDa.
应用
Fibrinogen was used in velocity variation assessment of red blood cell aggregation using spectral domain Doppler optical coherence tomography. It was also used to study the nano-bio interaction between graphite oxide nanoparticles and human blood components.
生化/生理作用
急性期蛋白，是蛋白质凝血级联反应的一部分。
纤维蛋白原是一种急性期蛋白，是蛋白质凝血级联反应的一部分。级联反应的最终结果是产生了将纤维蛋白原转化为纤维蛋白的凝血酶。凝血酶迅速蛋白水解纤维蛋白原，释放纤维蛋白肽A。这种小肽的丢失不足以使产生的纤维蛋白分子不溶解，但它倾向于与相邻的纤维蛋白和纤维蛋白原分子形成复合物。 然后凝血酶从纤维蛋白中裂解出第二种肽纤维蛋白肽B，然后形成的纤维蛋白单体自发聚合形成不溶性凝胶。聚合的纤维蛋白通过非共价键和静电力保持在一起，并被转酰胺酶，XIIIa因子稳定，XIIIa因子是凝血酶作用于XIII因子而产生的。然后不溶性纤维蛋白聚集体（凝块）和聚集的血小板阻塞受损的血管并防止进一步出血。血浆中纤维蛋白原的量可作为体内是否存在炎症过程的非特异性指标。来自任何哺乳动物来源的纤维蛋白原将被来自任何哺乳动物来源的凝血酶切割。
特点和优势
Source material has tested negative for HIV and HBsAg.
外形
Lyophilized powder containing ~15% sodium citrate and ~20% sodium chloride.
分析说明
Protein determined by biuret
储存分类代码
13 - Non Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Nano-Bio Interaction between Graphite Oxide Nano Particles and Human Blood Components
Hyoung-Mi Kim, Kyoung-Min Kim, Kyunghong Lee, Yoon Suk Kim and Jae-Min Oh
European Journal of Organic Chemistry, 5343-5349 (2012)
[The number of bacteria and fungi in "da-shan-zha-wan" pills].
Y Zhou
Zhong yao tong bao (Beijing, China : 1981), 10(12), 27-28 (1985-12-01)
Sachie Hiratsuka et al.
EMBO molecular medicine, 10(7) (2018-06-23)
Primary tumours establish metastases by interfering with distinct organs. In pre-metastatic organs, a tumour-friendly microenvironment supports metastatic cells and is prepared by many factors including tissue resident cells, bone marrow-derived cells and abundant fibrinogen depositions. However, other components are unclear.
Katarina Waldén et al.
The Annals of thoracic surgery, 97(4), 1199-1206 (2014-02-11)
Data from small selected patient populations suggest that the preoperative plasma concentration of fibrinogen influences postoperative blood loss and red blood cell transfusion after cardiac operations, but there are also conflicting reports. We assessed the importance of preoperative fibrinogen concentration
Keyvan Karkouti et al.
Anesthesia and analgesia, 117(1), 14-22 (2013-05-21)
Coagulopathy leading to excessive blood loss and large volume red cell transfusion is a frequent complication of cardiac surgery with cardiopulmonary bypass (CPB) that may be caused by low perioperative fibrinogen levels. We explored the relationship between post-CPB fibrinogen levels
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