Fas Ligand human

Fas ligand, a protein belonging to the tumor necrosis factor (TNF) family of cytokines, induces apoptosis in cells expressing the cell membrane receptor Fas (CD95/Apo-1).

Fas ligand, a protein belonging to the tumor necrosis factor (TNF) family of cytokines, induces apoptosis in cells expressing the cell membrane receptor Fas (CD95/Apo-1). FasL is expressed mainly in lymphoid tissue such as spleen and thymus and in a few other non lympoid tissues including the eye, testis and thyroid.
FasL is involved in immune down regulation and in the process of negative selection of T cells in the peripheral lymphoid organs. It also plays an important role in conferring immuno-privilege to the non-lymphoid tissues, such as eye and testis, in which it is expressed. It is suggested that constitutive FasL expression in a variety of tumors contributes to their immune evasion.
It has been shown that FasL is also involved in mediating inflammatory processes and can have pro-proliferative effects. The dual activity of FasL can be explained by diversion of the FasL signal to apoptosis of proliferation/differentiation, down stream of its receptor.

Activity: 0.5-5 ng/ml FasL induces apoptosis in Jurkat cells in the presence of 0.25-1 μg/ml ANTI-FLAG M2 monoclonal antibody as measured by caspase 3 activity.
This FLAG tagged FasL requires the presence of FLAG^® antibody for its aggregation and activation. The FLAG antibody is included in the set.

FLAG is a registered trademark of Merck KGaA, Darmstadt, Germany