F8682
Fosmidomycin sodium salt hydrate
≥95% (NMR)
别名:
(3-(Formylhydroxyamino)propyl)phosphonic acid sodium salt, (3-(N-Hydroxyformamido)propyl)phosphonic acid sodium salt, FR 31564
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关于此项目
经验公式（希尔记法）:
C4H10NO5P · xNa+ · yH2O
化学文摘社编号:
分子量:
183.10 (anhydrous free acid basis)
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
SMILES string
[P](=O)(O)(O)CCCN(O)C=O
InChI
1S/C4H10NO5P/c6-4-5(7)2-1-3-11(8,9)10/h4,7H,1-3H2,(H2,8,9,10)
InChI key
GJXWDTUCERCKIX-UHFFFAOYSA-N
assay
≥95% (NMR)
form
powder
storage condition
desiccated
color
white to beige
solubility
H2O: 20 mg/mL, clear
storage temp.
−20°C
Quality Level
Application
Fosmidomycin sodium salt hydrate has been used as an inhibitor of 1-deoxy-D-xylulose 5-phosphate reductoisomerase in a study to determine monotropin carvacrol biosynthesis in Satureja khuzistanica plant.
Biochem/physiol Actions
Fosmidomycin is an inhibitor of 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) (MEP synthase): an antimalarial compound.
Fosmidomycin is an inhibitor of 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) (MEP synthase): an antimalarial compound. 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) is an enzyme involved in the first step in the nonmevalonate pathway for isoprenoid biosynthesis in Gram-negative, Gram-positive bacteria, plants, and the parasite causing the most virulent form of malaria, Plasmodium falciparum (Mammals produce isoprenoids via the mevalonate pathway).
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
涉药品监管产品
此项目有
The expression of 1-deoxyhezylolose 5-phosphate reductase isomerase and its relation with monotropene carvacrol biosynthesis in Khuzestan Satureja plant
Ramak P, et al.
Journal of Plant Biology, 27(4), 622-634 (2015)
Sarah Ponaire et al.
European journal of medicinal chemistry, 51, 277-285 (2012-03-13)
Since Mycobacterium tuberculosis sets up several multiple anti-tuberculosis drug resistance mechanisms, development of new drugs with innovative target is urgent. The methylerythritol phosphate pathway (MEP) involved in the biosynthesis of essential metabolites for the survival of mycobacteria, represents such a
Jan-Ytzen van der Meer et al.
Natural product reports, 29(7), 721-728 (2012-05-05)
Due to the increase in resistance of Plasmodium spp. against available antimalarials, there is a need for new, effective and innovative drugs. The non-mevalonate pathway for the biosynthesis of the universal isoprenoid precursors, which is absent in humans, is suggested
Matthew A DeSieno et al.
Chemical communications (Cambridge, England), 47(36), 10025-10027 (2011-08-11)
The Fe(II) and α-ketoglutarate-dependent hydroxylase FrbJ was previously demonstrated to utilize FR-900098 synthesizing a second phosphonate FR-33289. Here we assessed its ability to hydroxylate other possible substrates, generating a library of potential antimalarial compounds. Through a series of bioassays and
Robert R Junker et al.
Journal of chemical ecology, 37(12), 1323-1331 (2011-12-14)
In their natural environment, plants are synchronously confronted with mutualists and antagonists, and thus benefit from signals that contain messages for both functional groups of interaction partners. Floral scents are complex blends of volatiles of different chemical classes, including benzenoids
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