FM19G11

Name: FM19G11
Brand: SIGMA

≥98% (HPLC)

别名:

3-[(2,4-Dinitrobenzoyl)amino]-benzoic acid 2-(4-methylphenyl)-2-oxoethyl ester, [2-oxo-2-(p-tolyl)ethyl] 3-[(2,4-dinitrobenzoyl)amino]benzoate

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所有图片(1)

About This Item

经验公式（希尔记法）:

C₂₃H₁₇N₃O₈

CAS Number:

329932-55-0

分子量:

463.40

MDL编号:

MFCD01174289

UNSPSC代码:

12352200

PubChem化学物质编号:

329799774

NACRES:

NA.77

质量水平

100

方案

≥98% (HPLC)

表单

powder

颜色

off-white to light brown

溶解性

DMSO: ≥40 mg/mL

储存温度

2-8°C

SMILES字符串

Cc1ccc(cc1)C(=O)COC(=O)c2cccc(NC(=O)c3ccc(cc3[N+]([O-])=O)[N+]([O-])=O)c2

InChI

1S/C23H17N3O8/c1-14-5-7-15(8-6-14)21(27)13-34-23(29)16-3-2-4-17(11-16)24-22(28)19-10-9-18(25(30)31)12-20(19)26(32)33/h2-12H,13H2,1H3,(H,24,28)

InChI key

XVUOIWIIQVGWAJ-UHFFFAOYSA-N

应用

FM19G11 has been used as ahypoxia-inducible factor-1α (HIF- 1α):

to study the effects ofFM19G11-loaded gold nanoparticles (NPs) on self-renewal and proliferation of ependymal stem progenitor cells (epSPCs) of mice
to study its effects on the O6-methylguanine DNA-methyltransferase (MGMT) expression in glioblastoma (GBM) cells
to study its effects on microphthalmia-associated transcription factor (MITF) expression in melanoma cell line

生化/生理作用

FM19G11 is an inhibitor of Hypoxia Inducible Factor α (HIFα), reported to affect self-renewal and differentiation of stem cells.

FM19G11 is an inhibitor of Hypoxia Inducible Factors α (HIFα), reported to affect self-renewal and differentiation of stem cells. Hypoxia-inducible factors (HIFs) are transcription factors that respond to changes in available oxygen in the cellular environment. Among other functions (like angiogenesis), HIFα proteins affect the self-renewal and the differentiation processes of stem cells. FM19G11 inhibits the HIFα proteins that repress the target genes of the two α subunits, in various tumor cell lines as well as in adult and embryonic stem cell (ESC) models.