F9429
Anti-FBI-1/Pokemon (C-terminal) antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
别名:
Anti-FBI-1, Anti-LRF, Anti-POK Erythroid Myeloid Ontogenic Factor, Anti-ZBTB7, Anti-Zinc Finger- and BTB Domain-containing Protein 7
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关于此项目
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ARR, IP, WB
Citations:
7
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 75 kDa (additional band at 70 kDa may be seen)
species reactivity
human
technique(s)
immunoprecipitation (IP): 1-2 μg using A431 cell lysates, microarray: suitable, western blot: 0.5-1 μg/mL using K-562 cell lysates
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... ZBTB7A(51341)
General description
FBI-1/Pokemon is a BTB/POZ containing zinc-finger protein. It is predominantly expressed in a subset of T-cell lymphoma and B-cell lymphomas. It is also found in breast, lung, colon, prostate, and bladder carcinomas. It was identified as a critical factor in oncogenesis and is called Pokemon (POK erythroid myeloid ontogenic factor).
Immunogen
synthetic peptide corresponding to amino acids 570-584 of human FBI-1/Pokemon, conjugated to KLH.
Application
Anti-FBI-1/Pokemon (C-terminal) antibody is suitable for immunoprecipitation at concentration of 1-2μg using A431 cell lysates, microarray and western blot at concentration of 0.5-1μg/mL using K-562 cell lysates.
Biochem/physiol Actions
FBI-1/Pokemon (C-Terminal) act as potent transcriptional repressors through the recruitment of histone deacetylases (HDACs) and subsequent chromatin remodeling. By binding to the tumor suppressor gene ARF, the Pokemon exerts its oncogenic activity.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, and 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
新产品
此项目有
O Albagli et al.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, 6(9), 1193-1198 (1995-09-01)
The BTB/POZ domain defines a newly characterized protein-protein interaction interface. It is highly conserved throughout metazoan evolution and generally found at the NH2 terminus of either actin-binding or, more commonly, nuclear DNA-binding proteins. By mediating protein binding in large aggregates
All in the family: the BTB/POZ, KRAB, and SCAN domains.
T Collins et al.
Molecular and cellular biology, 21(11), 3609-3615 (2001-05-08)
Takahiro Maeda et al.
Cancer research, 65(19), 8575-8578 (2005-10-06)
Learning how critical cell regulatory pathways are controlled may lead to new opportunities for cancer treatment. We recently identified the transcription factor Pokemon as a central regulator of the important tumor suppressor ARF. Pokemon is overexpressed in multiple human cancers
Ari Melnick et al.
Molecular and cellular biology, 22(6), 1804-1818 (2002-02-28)
The PLZF (promyelocytic leukemia zinc finger) transcriptional repressor, when fused to retinoic acid receptor alpha (RARalpha), causes a refractory form of acute promyelocytic leukemia. The highly conserved N-terminal BTB (bric a brac, tramtrack, broad complex)/POZ domain of PLZF plays a
J M Davies et al.
Oncogene, 18(2), 365-375 (1999-02-02)
BTB/POZ-domain C2H2 zinc(Zn)-finger proteins are encoded by a subfamily of genes related to the Drosophila gap gene krüppel. To date, two such proteins, PLZF and LAZ-3/BCL-6, have been implicated in oncogenesis. We have now identified a new member of this
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