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F9505

呋喃唑酮

Name: 呋喃唑酮
Brand: SIGMA

别名:

3-(5-硝基呋喃甲叉氨基)-2-噁唑烷酮

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关于此项目

经验公式（希尔记法）:

C₈H₇N₃O₅

化学文摘社编号:

67-45-8

分子量:

225.16

UNSPSC Code:

51102829

NACRES:

NA.85

PubChem Substance ID:

24894997

EC Number:

200-653-3

Beilstein/REAXYS Number:

8317414

MDL number:

MFCD00010550

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biological source

synthetic

Quality Level

200

form

powder

color

yellow

mp

256-256 °C

solubility

formic acid: 50 mg/mL

antibiotic activity spectrum

Gram-positive bacteria, parasites

mode of action

enzyme | inhibits

SMILES string

[O-][N+](=O)c1ccc(\C=N\N2CCOC2=O)o1

InChI

1S/C8H7N3O5/c12-8-10(3-4-15-8)9-5-6-1-2-7(16-6)11(13)14/h1-2,5H,3-4H2/b9-5+

InChI key

PLHJDBGFXBMTGZ-WEVVVXLNSA-N

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Application

呋喃唑酮是硝基呋喃衍生物，具有抗原虫和抗菌活性。呋喃唑酮与细菌 DNA 结合，从而导致单胺氧化酶逐渐受到抑制。用于治疗厌食和拮抗家禽对硫胺素的利用。呋喃唑酮增加鸡心肌细胞中对毒胡萝卜素敏感的 Ca ²⁺-atp 酶。

Biochem/physiol Actions

呋喃唑酮及其产生的自由基，可能与 DNA 结合并诱导交联。细菌 DNA 对本药特别敏感，从而导致细菌染色体的高水平突变（转换和颠换）。其作用机制使耐药生物体的发展最小化。呋喃唑酮是一种单胺氧化酶 (MAO) 抑制剂，用作 DNA 链间交联剂。

pictograms

GHS08

signalword

Warning

hcodes

H361fd

pcodes

P201 - P202 - P280 - P308 + P313 - P405 - P501

Hazard Classifications

Repr. 2

存储类别

11 - Combustible Solids

wgk

WGK 3

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Anorexia and antagonism of thiamin utilization in poultry treated with furazolidone.

B H Ali et al.

Quarterly journal of experimental physiology (Cambridge, England), 67(3), 437-448 (1982-07-01)

Furazolidone (0.4% w/w in the feed, 10 days) reduced the feed intake and growth in 9 week old chickens, and increased the amount of 5-hydroxytryptamine (5-HT) in the brain. The drug also increased the stimulation of transketolase activity by thiamine

Am J Physiol Heart Circ Physiol. Furazolidone increases thapsigargin-sensitive Ca²⁺-ATPase in chick cardiac myocytes

D. Lax, R. Martinez-Zaguilan, et al.

American Journal of Physiology. Heart and Circulatory Physiology, 267, H734-H741 (1994)

Some pharmacological and toxicological properties of furazolidone.

B H Ali

Veterinary research communications, 6(1), 1-11 (1983-01-01)

The pharmacological and toxicological properties of furazolidone have been briefly reviewed. Among the most important pharmacological actions of furazolidone is the inhibition of mono- and diamine oxidase activities, which seem to depend, at least in some species, on the presence

Pharmacology and toxicity of furazolidone in man and animals: some recent research.

B H Ali

General pharmacology, 20(5), 557-563 (1989-01-01)

Furazolidone induced oxidative DNA damage via up-regulating ROS that caused cell cycle arrest in human hepatoma G2 cells.

Xi Jin et al.

Toxicology letters, 201(3), 205-212 (2011-01-05)

Furazolidone (FZD) is an antimicrobial agent that has been shown to have mutagenic, genotoxic and potentially carcinogenic properties when tested in a variety of systems in vitro and in vivo. In this study, we investigated FZD's DNA damaging effect in

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全球贸易项目编号

货号	GTIN
F9505-10G	04061833621721
F9505-100G	04061832991153
F9505-25G	04061833621776

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