FLAAS
腺苷 5′-三磷酸腺苷 (ATP) 二钠盐 水合物
≥90%, bacterial (Corynebacterium sp), lyophilized powder
别名:
ATP 二钠 水合物
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关于此项目
线性分子式:
C10H14N5O13P3Na2 · xH2O
CAS Number:
分子量:
551.14 (anhydrous basis)
EC 号:
MDL编号:
UNSPSC代码:
12352202
eCl@ss:
32160414
PubChem化学物质编号:
NACRES:
NA.26
Product Name
腺苷 5′-三磷酸腺苷 (ATP) 二钠盐 水合物, vial of ~1 mg ATP
生物来源
bacterial (Corynebacterium sp)
质量水平
方案
≥90%
表单
lyophilized powder
包装
vial of ~1 mg ATP
溶解性
water: soluble, clear, colorless (1 vial + 0.1 mL)
储存温度
−20°C
SMILES字符串
Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]3O
InChI
1S/C10H16N5O13P3.2Na.H2O/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20;;;/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20);;;1H2/q;2*+1;/p-2/t4-,6-,7-,10-;;;/m1.../s1
InChI key
NTBQNWBHIXNPRU-MSQVLRTGSA-L
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应用
腺苷5′-三磷酸盐(ATP)二钠盐水合物用作：
- 生物发光法测定ATP的标准物
- 激酶缓冲液，以评估死亡相关蛋白激酶(DAPK2)与14-3-3-β之间的相互作用
- ATP比色测定的标准
生化/生理作用
5′-三磷酸腺苷通过清除TNF-α的分泌和促进白介素-10的分泌，发挥对炎症反应的抑制作用。
P2 嘌呤能激动剂；增加 Ca2+-激活的 K+ 通道的活性；ATP-依赖酶系统的底物
腺苷5′-三磷酸(ATP)是存在于生命系统中的一种核苷三磷酸。它控制着各种生物过程，如葡萄糖代谢、肌肉收缩和神经传递等。除此之外，ATP还是细胞重要的能量来源。ATP的应用对非小细胞肺癌的治疗可能有用。
制备说明
制备过程基本无钒。
每小瓶含 ~1.2mg Na2ATP • 3H2O，相当于 ~1.0mg ATP (2.0μmol)。标签上印有实际含量。
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Identification of novel death-associated protein kinase 2 interaction partners by proteomic screening coupled with bimolecular fluorescence complementation
Geering B, et al.
Molecular and Cellular Biology, 36(1), 132-143 (2016)
Jie Ge et al.
Journal of medicinal chemistry, 49(15), 4606-4615 (2006-07-21)
17-Allylamino-17-demethoxygeldanamycin (17-AAG)1 is a semisynthetic inhibitor of the 90 kDa heat shock protein (Hsp90) currently in clinical trials for the treatment of cancer. However, 17-AAG faces challenging formulation issues due to its poor solubility. Here we report the synthesis and
Randomized clinical trial of adenosine 5?-triphosphate in patients with advanced non-small-cell lung cancer
Agteresch HJ, et al.
Journal of the National Cancer Institute, 92(4), 321-328 (2000)
Els L R Swennen et al.
European journal of immunology, 35(3), 852-858 (2005-02-19)
In vitro studies suggest that extracellular nucleotides and nucleosides may be important regulators of inflammatory and immune responses. Most studies with adenosine 5'-triphosphate (ATP) have been performed in cell lines, which are remote from the human situation. The purpose of
Schuichi Koizumi et al.
Nature, 446(7139), 1091-1095 (2007-04-06)
Microglia, brain immune cells, engage in the clearance of dead cells or dangerous debris, which is crucial to the maintenance of brain functions. When a neighbouring cell is injured, microglia move rapidly towards it or extend a process to engulf
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