G0170
Anti-GABAA Receptor (α4 subunit), N-Terminus antibody produced in rabbit
affinity isolated antibody, buffered aqueous glycerol solution
别名:
Anti-γ-Aminobutyric Acid Type A Receptor (α4 subunit)
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous glycerol solution
用途
sufficient for 10 blots
分子量
antigen (active form) ~64 kDa
种属反应性
rat
技术
immunoprecipitation (IP): suitable
western blot: 1:1,000-1:2,000 using rat brain lysate
UniProt登记号
运输
wet ice
储存温度
−20°C
基因信息
rat ... Gabra4(140675)
一般描述
Gamma-aminobutyric acid (GABA) receptor is the multifunctional, pentameric membrane proteins that operate GABA-gated chloride channels. It acts as major inhibitory neurotransmitter in the adult mammalian brain. It is a member of the neurotransmitter ligand-gated ion channels which plays various functions in the central nervous system, the peripheral nervous system, and in some non-neuronal tissues. At least four types of subunits (α, β, γ and δ) of GABA have been identified. Generally it contains one type of α and β subunit, and a single γ polypeptide in a ratio of 2:2:1.
免疫原
synthetic peptide from the N-terminus of the rat GABAA receptor α4 subunit.
应用
Anti-GABAA Receptor (α4 subunit), N-Terminus antibody is suitable for immunoprecipitation and western blot at a dilution of 1:1,000-1:2,000 using rat brain lysate.
生化/生理作用
GABA is synthesized primarily from glutamate by glutamate decarboxylase (GAD). It is triggered by binding to its ligand-gated chloride channels, GABA(A) and GABA(C) as well as metabotropic receptor GABA(B). Along with neural development, it is also involved in a wide variety of physiological functions in tissues and organs outside the brain.
外形
Solution in 10 mM HEPES, pH 7.5, 150 mM NaCl, 100 μg/mL BSA and 50% glycerol.
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储存分类代码
10 - Combustible liquids
法规信息
新产品
此项目有
Richard W Olsen et al.
Neuropharmacology, 56(1), 141-148 (2008-09-02)
This mini-review attempts to update experimental evidence on the existence of GABA(A) receptor pharmacological subtypes and to produce a list of those native receptors that exist. GABA(A) receptors are chloride channels that mediate inhibitory neurotransmission. They are members of the
U Rudolph et al.
Trends in pharmacological sciences, 22(4), 188-194 (2001-04-03)
The enhancement of GABA-mediated synaptic transmission underlies the pharmacotherapy of various neurological and psychiatric disorders. GABA(A) receptors are pluripotent drug targets that display an extraordinary structural heterogeneity: they are assembled from a repertoire of at least 18 subunits (alpha1-6, beta1-3
Structure and pharmacology of vertebrate GABAA receptor subtypes.
P J Whiting et al.
International review of neurobiology, 38, 95-138 (1995-01-01)
H Möhler et al.
Current opinion in pharmacology, 1(1), 22-25 (2001-11-20)
The GABA(A) receptor is a pluripotent drug target mediating anxiolytic, sedative, anticonvulsant, muscle relaxant and amnesic activity. These drug actions have now been attributed to defined receptor subtypes. Thus, precise guidelines are available for the development of novel drugs with
Masahito Watanabe et al.
International review of cytology, 213, 1-47 (2002-02-12)
Gamma-aminobutyrate (GABA) is a major inhibitory neurotransmitter in the adult mammalian brain. GABA is also considered to be a multifunctional molecule that has different situational functions in the central nervous system, the peripheral nervous system, and in some nonneuronal tissues.
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