G4256
Galactose-1-phosphate Uridyltransferase from galactose-adapted yeast
Type IV, lyophilized powder, 20-60 units/mg protein (modified Warburg-Christian)
别名:
GALT, UDP glucose:α-D-galactose-1-phosphate uridyltransferase
类型
Type IV
表单
lyophilized powder
比活
20-60 units/mg protein (modified Warburg-Christian)
组成
Protein, 15-35%
异质活性
6-phosphogluconate dehydrogenase ≤0.5%
UDP glucose pyrophosphorylase and galactokinase ≤0.2%
储存温度
−20°C
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一般描述
Research area: Cell Signaling
Galactose-1-phosphate uridyltransferase (GALT) is a galactose metabolizing enzyme that facilitates the simultaneous conversion of uridine diphosphoglucose (UDP-glucose) and galactose-1-phosphate (gal-1P) to uridine diphosphogalactose (UDP-galactose) and glucose-1-phosphate. Classic Galactosemia (CG) is an inherited metabolic condition caused by deficiency of GALT activity. GALT gene is mapped to human chromosome 9p13. Deficiency of GALT results in type 1 galactosemia.
Galactose-1-phosphate uridyltransferase (GALT) is a galactose metabolizing enzyme that facilitates the simultaneous conversion of uridine diphosphoglucose (UDP-glucose) and galactose-1-phosphate (gal-1P) to uridine diphosphogalactose (UDP-galactose) and glucose-1-phosphate. Classic Galactosemia (CG) is an inherited metabolic condition caused by deficiency of GALT activity. GALT gene is mapped to human chromosome 9p13. Deficiency of GALT results in type 1 galactosemia.
应用
Galactose-1-phosphate Uridyltransferase from galactose-adapted yeast has been used to perform enzyme assays.
外形
Contains buffer salts as citrate and reduced glutathione
其他说明
One unit will form 1.0 μmole of glucose 1-phosphate from UDP-glucose, galactose 1-phosphate and NADP+ per min at pH 8.7 at 25 °C as detected by a coupled system using phosphoglucomutase.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
此项目有
En route to deoxygenated N-acetyllactosamine analogues employing uridyl and galactosyl transferases.
Daniel Lazarevic et al.
Carbohydrate research, 344(12), 1449-1452 (2009-06-30)
All monodeoxygenated galactoses were treated with galactokinase, and for the 2-, 3-, and 4-deoxy compounds, transformation into the corresponding galactopyranosyl phosphates could be observed. In case of the 2-deoxy derivative, further reaction via UDP-2-deoxy-D-lyxo-hexose (UDP-2-deoxygalactose), which was also obtained chemically
E Crushell et al.
Journal of inherited metabolic disease, 32(3), 412-415 (2009-05-07)
Classical galactosaemia is relatively common in Ireland due to a high carrier rate of the Q188R GALT mutation. It is screened for using a bacterial inhibition assay (BIA) for free galactose. A Beutler assay on day one of life is
J M Flanagan et al.
Heredity, 104(2), 148-154 (2009-07-30)
Classical or transferase-deficient galactosaemia is an inherited metabolic disorder caused by mutation in the human Galactose-1-phosphate uridyl transferase (GALT) gene. Of some 170 causative mutations reported, fewer than 10% are observed in more than one geographic region or ethnic group.
Deborah S Barbouth et al.
Pediatric research, 62(6), 720-724 (2007-10-25)
Classic galactosemia is caused by impaired galactose-1-phosphate uridyltransferase (GALT EC 2.7.712). If discovered and treated within the first days of life, the acute problems of hepatocellular damage, sepsis, and death are prevented. However, chronic problems such as ataxia, tremor, dyspraxic
Jane Odhiambo Mumma et al.
Molecular genetics and metabolism, 93(2), 160-171 (2007-11-06)
Galactose is metabolized in humans and other species by the three-enzyme Leloir pathway comprised of galactokinase (GALK), galactose 1-P uridylyltransferase (GALT), and UDP-galactose 4'-epimerase (GALE). Impairment of GALT or GALE in humans results in the potentially lethal disorder galactosemia, and
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