G7048
氯胍 盐酸盐
≥95% (HPLC)
别名:
Chlorguanide, N1-(4-Chlorophenyl)-N5-isopropylbiguanide
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关于此项目
经验公式（希尔记法）:
C11H16ClN5·HCl
化学文摘社编号:
分子量:
290.19
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
51101906
EC Number:
211-283-7
MDL number:
Assay:
≥95% (HPLC)
Form:
solid
Storage condition:
desiccated
Quality Segment
assay
≥95% (HPLC)
form
solid
storage condition
desiccated
solubility
acetonitrile: water: ~1 mg/mL (60/40)
originator
AstraZeneca
storage temp.
2-8°C
SMILES string
Cl.CC(C)NC(=N)NC(=N)Nc1ccc(Cl)cc1
InChI
1S/C11H16ClN5.ClH/c1-7(2)15-10(13)17-11(14)16-9-5-3-8(12)4-6-9;/h3-7H,1-2H3,(H5,13,14,15,16,17);1H
InChI key
SARMGXPVOFNNNG-UHFFFAOYSA-N
Application
Proguanil (chlorguanide) may be used in anti-parasitic protozoan drug development to study its pharmacokinetics, metabolism, safety, efficacy and methods of delivery as an antimalarial drug.
Biochem/physiol Actions
Chlorguanide (proguanil) is combined with atovaquone for malaria prophylaxis. The two compounds act synergistically to inhibit the plasmodial dihydrofolate reductase (DHFR) and interrupt the electron transport chain. Mutations in DHFR account for the development of resistant strains.
Proguanil hydrochloride is antimalarial. Dihydrofolate reductase inhibitor
Features and Benefits
This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable