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Merck
CN

G8171

Sigma-Aldrich

藤黄酸

≥95% (HPLC), powder

别名:

β-藤黄酸, 1,5-甲醇-1H,3H,11H-呋喃(3,4-g)吡喃(3,2-b)氧杂蒽-1-巴豆酸, B"-Guttiferrin, 藤黄酸

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关于此项目

经验公式（希尔记法）:
C38H44O8
化学文摘社编号:
2752-65-0
分子量:
628.75
UNSPSC代码:
12352200
PubChem化学物质编号:
329799975

主要文件

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方案

≥95% (HPLC)

表单

powder

颜色

yellow to orange

溶解性

DMSO: ≥10 mg/mL
H2O: insoluble

储存温度

−20°C

SMILES字符串

C\C(C)=C\CC[C@@]1(C)Oc2c(C\C=C(\C)C)c3O[C@@]45[C@@H]6C[C@@H](C=C4C(=O)c3c(O)c2C=C1)C(=O)[C@]5(C\C=C(\C)C(O)=O)OC6(C)C

InChI

1S/C38H44O8/c1-20(2)10-9-15-36(8)16-14-24-29(39)28-30(40)26-18-23-19-27-35(6,7)46-37(33(23)41,17-13-22(5)34(42)43)38(26,27)45-32(28)25(31(24)44-36)12-11-21(3)4/h10-11,13-14,16,18,23,27,39H,9,12,15,17,19H2,1-8H3,(H,42,43)/b22-13-/t23-,27+,36-,37+,38-/m1/s1

InChI key

GEZHEQNLKAOMCA-RRZNCOCZSA-N

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生化/生理作用

藤黄酸可作为半胱天冬酶活化剂和细胞凋亡诱导剂。
藤黄酸可作为半胱天冬酶活化剂和细胞凋亡诱导剂，在细胞周期的G2/M期引起不可逆的停滞。

特点和优势

该化合物在受体分类和信号转导手册的 半胱天冬酶 页面上有详细描述。如需浏览其他手册页面，请点击此处。

象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险分类

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
034M4737V
121M4705V
111M4710V
088K47103
088K47102

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Li-jing Yang et al.
Acta pharmacologica Sinica, 34(2), 191-198 (2013-01-01)
Gambogic acid (GA) is the main active ingredient of gamboge, a brownish to orange dry resin secreted from Garcinia hanburyi, a plant that is widely distributed in nature. Recent in vitro and in vivo studies have demonstrated that GA exerts
Tao Chen et al.
Molecules (Basel, Switzerland), 17(6), 6249-6268 (2012-05-29)
Gambogic acid (GA) is in a phase II clinical trial as an antitumor and antiangiogenesis agent. In this study, 36 GA derivatives were synthesized and screened in a zebrafish model to evaluate their antiangiogenic activity and toxicity. Derivatives 4, 32
Haopeng Sun et al.
European journal of medicinal chemistry, 51, 110-123 (2012-04-05)
Previously we have reported a series of gambogic acid's analogs and have identified a compound that possessed comparable in vitro growth inhibitory effect as gambogic acid. However, their target protein as well as the key pharmacophoric motifs on the target have
Jing Yang et al.
Journal of natural products, 75(6), 1108-1116 (2012-06-06)
Gambogic acid (1) is a cytotoxic caged xanthone derived from the resin of Garcinia hanburyi. Compound 1 selectively induces apoptosis in cancer cells, at least partially, by targeting the stress response to reactive oxygen species (ROS). However, the molecular mechanism
Jing Geng et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 62(2), 165-172 (2012-10-16)
Gambogic acid (GBA) targeted Heat shock protein 90 (Hsp90) and prohibited TNF-α/NF-κB signaling pathway. It can be inferred that the anti-inflammatory activity of GBA results from inhibiting the cytokine production via NF-κB signaling pathway. We used the RAW264.7 cell line
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