G9267
Glutathionesulfonic acid
别名:
Glutathione sulfonate
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关于此项目
经验公式（希尔记法）:
C10H17N3O9S
化学文摘社编号:
分子量:
355.32
NACRES:
NA.26
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI
1S/C10H17N3O9S/c11-5(10(18)19)1-2-7(14)13-6(4-23(20,21)22)9(17)12-3-8(15)16/h5-6H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)(H,20,21,22)
SMILES string
NC(CCC(=O)NC(CS(O)(=O)=O)C(=O)NCC(O)=O)C(O)=O
InChI key
QGWRMTHFAZVWAM-UHFFFAOYSA-N
assay
≥98% (TLC)
form
powder
technique(s)
ligand binding assay: suitable
color
white
storage temp.
2-8°C
Biochem/physiol Actions
Glutathionesulfonic acid (GSO3), a metabolite of glutathione, is used to increase the tissue-to-plasma concentration ratio of thiopental sodium. Glutathione sulfonate is also used as a modulator of dopamine release and to study glutathione binding sites on proteins such as glutathione transferase.
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Yuhsuke Ohkawa et al.
Biological & pharmaceutical bulletin, 25(6), 761-765 (2002-06-26)
The effects of glutathione (GSH) and glutathionesulfonic acid sodium salt [N-(N-gamma-L-glutamyl-L-beta-sulfoalanyl)glycine sodium salt, GSO3Na], which is a minor metabolite of GSH, on the pharmacokinetics of thiopental sodium were investigated in rats. The concomitant use of GSO3Na with thiopental sodium significantly
Réka Janáky et al.
Neurochemical research, 32(8), 1357-1364 (2007-04-03)
Glutathione (gamma-glutamylcysteinylglycine, GSH and oxidized glutathione, GSSG), may function as a neuromodulator at the glutamate receptors and as a neurotransmitter at its own receptors. We studied now the effects of GSH, GSSG, glutathione derivatives and thiol redox agents on the
David Balchin et al.
Biophysical chemistry, 156(2-3), 153-158 (2011-05-03)
A C-terminal helix (α9) adjacent to the active site on each subunit is a structural feature unique to the alpha isoform of glutathione transferases which contributes to the catalytic and ligandin functions of the enzyme. The ionisation state of Tyr-9
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