产品名称
谷胱甘肽还原酶 人, buffered aqueous solution, ≥10 units/mg protein, recombinant, expressed in E. coli
recombinant
expressed in E. coli
form
buffered aqueous solution
specific activity
≥10 units/mg protein
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Quality Level
Gene Information
human ... GSR(2936)
Application
人谷胱甘肽还原酶已被用于:
- 谷胱甘肽还原酶活性测定
- 氧化强制降解分析
- 氧化还原试验
Biochem/physiol Actions
人谷胱甘肽还原酶适合用作细胞生长抑制和抗疟药物。通过使用特定抑制剂抑制酶,它可以类似蚕豆病的方式来抗疟疾。
谷胱甘肽还原酶是一种同源二聚体酶,每个亚基含有 1 个 FAD 分子和 1 个 NADPH 结合域。 人 GR (hGR) 和 恶性疟原虫 GR (PfGR) 对于疟原虫在人红细胞内的生存是必需的。因此,这种酶可用于候选抗疟疾试剂的研究。
谷胱甘肽还原酶是一种普遍存在的黄酶,参与细胞应激的保护。
谷胱甘肽还原酶是一种普遍存在的黄酶,参与细胞应激的保护。谷胱甘肽还原酶催化氧化型谷胱甘肽 (GSSG) 还原成谷胱甘肽 (GSH)。对维持足够水平的还原型细胞 GSH(作为与自由基和有机过氧化物反应的抗氧化剂)的谷胱甘肽氧化还原循环至关重要。谷胱甘肽还是谷胱甘肽过氧化物酶的电子供体,也是谷胱甘肽 S-转移酶的底物,有助于解毒和消除有毒亲电代谢物和外源性物质。
Disclaimer
除非我们的目录或产品随附的其他公司文件中另有说明,否则我们的产品预期仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、 体外 诊断用途、 离体 或 体内 治疗用途或任何类型的消费或人类或动物应用。
General description
研究领域:细胞信号传导。谷胱甘肽还原酶属于同型二聚体FAD−二硫键氧化还原酶家族成员,具有两个高度保守的罗斯曼折叠结构域,其中一个结合还原型烟酰胺腺嘌呤二核苷酸磷酸(NADPH)和黄素腺嘌呤二核苷酸(FAD),另一个是界面二聚化结构域。该酶倾向于积聚在细胞生成活性氧的富电子区。
Other Notes
在 pH 7.5、25°C 下 1 个单位将还原 1.0μmol DTNB/min
Physical form
含 25 mM Tris-HCl (pH 7.4)、1 mM EDTA 和 50% (v/v) 甘油的溶液。
存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
此项目有
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