Merck
CN

G9297

Sigma-Aldrich

谷胱甘肽还原酶 人

buffered aqueous solution, ≥10 units/mg protein, recombinant, expressed in E. coli

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别名:
GR, NADPH:氧化型谷胱甘肽氧化还原酶, 谷胱甘肽二硫键还原酶
CAS号:
MDL编号:
NACRES:
NA.41

重组

expressed in E. coli

质量水平

形式

buffered aqueous solution

specific activity

≥10 units/mg protein

UniProt登记号

运输

wet ice

储存温度

−20°C

Gene Information

human ... GSR(2936)

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G3664SAB4200182T7915
Glutathione Reductase human buffered aqueous solution, ≥10 units/mg protein, recombinant, expressed in E. coli

Sigma-Aldrich

G9297

谷胱甘肽还原酶 人

form

buffered aqueous solution

form

ammonium sulfate suspension

form

buffered aqueous solution

form

ammonium sulfate suspension

specific activity

≥10 units/mg protein

specific activity

100-300 units/mg protein (biuret)

specific activity

-

specific activity

>25 units/mg protein (Bradford)

UniProt accession no.

P00390

UniProt accession no.

P41921

UniProt accession no.

P00390

UniProt accession no.

P0A9P4

shipped in

wet ice

shipped in

-

shipped in

dry ice

shipped in

-

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

应用

人谷胱甘肽还原酶已被用于:
  • 谷胱甘肽还原酶活性测定
  • 氧化强制降解分析
  • 氧化还原试验

生化/生理作用

谷胱甘肽还原酶是一种同源二聚体酶,每个亚基含有 1 个 FAD 分子和 1 个 NADPH 结合域。 人 GR (hGR) 和 恶性疟原虫 GR (PfGR) 对于疟原虫在人红细胞内的生存是必需的。因此,这种酶可用于候选抗疟疾试剂的研究。
谷胱甘肽还原酶是一种普遍存在的黄酶,参与细胞应激的保护。谷胱甘肽还原酶催化氧化型谷胱甘肽 (GSSG) 还原成谷胱甘肽 (GSH)。对维持足够水平的还原型细胞 GSH(作为与自由基和有机过氧化物反应的抗氧化剂)的谷胱甘肽氧化还原循环至关重要。谷胱甘肽还是谷胱甘肽过氧化物酶的电子供体,也是谷胱甘肽 S-转移酶的底物,有助于解毒和消除有毒亲电代谢物和外源性物质。

单位定义

在 pH 7.5、25°C 下 1 个单位将还原 1.0μmol DTNB/min

外形

含 25 mM Tris-HCl (pH 7.4)、1 mM EDTA 和 50% (v/v) 甘油的溶液。

免责声明

除非我们的目录或产品随附的其他公司文件中另有说明,否则我们的产品预期仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、 体外 诊断用途、 离体 或 体内 治疗用途或任何类型的消费或人类或动物应用。

储存分类代码

10 - Combustible liquids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

法规信息

常规特殊物品

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