生物来源
chicken
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
种属反应性
mouse, rat, human
制造商/商品名称
Genway 15-288-22309F
技术
western blot: suitable
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... CDK4(1019)
应用
Anti-CDK4 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
生化/生理作用
Cyclin-dependent kinase 4 (also known as cell division protein kinase 4) is an enzyme encoded by the CDK4 gene in humans. It is highly expressed in nasopharyngeal carcinomas (NPC). CDK4 phosphorylates and inactivates retinoblastoma (Rb) protein family members in association with cyclin-D. It mediates progression through the G1- to the S-phase of the cell cycle. Over expression of CDK4 is mostly independent with gene amplification and is a potential prognostic biomarker in NPC and may indicate tumor aggressiveness through cell cycle dysregulation. It is the main molecular feature of well-differentiated liposarcomas (WDLS) and dedifferentiated liposarcomas (DDLS). Inhibition of CDK4 partly restores G(1)-S arrest and sensitizes cells to doxorubicin-mediated cell death in MYCN-amplified cells with an intact p53 pathway. CDK4 up-regulation takes place in oral cancer progression.
外形
Solution in phosphate buffered saline containing 0.02% sodium azide.
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储存分类代码
12 - Non Combustible Liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
新产品
此项目有
Tzu-Ju Chen et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 35(7), 7209-7216 (2014-04-29)
Data mining in the public domain demonstrates that cyclin-dependent kinase 4 (CDK4) is highly expressed in nasopharyngeal carcinomas (NPC). Associated with cyclin-D, CDK4 phosphorylates and inactivates retinoblastoma (Rb) protein family members and mediates progression through the G1- to the S-phase
Sina Gogolin et al.
Cell cycle (Georgetown, Tex.), 12(7), 1091-1104 (2013-03-07)
Relapse with drug-resistant disease is the main cause of death in MYCN-amplified neuroblastoma patients. MYCN-amplified neuroblastoma cells in vitro are characterized by a failure to arrest at the G(1)-S checkpoint after irradiation- or drug-induced DNA damage. We show that several
Ming J Poi et al.
Anticancer research, 34(7), 3285-3292 (2014-07-02)
While aberrant expression of cyclin-dependent kinase-4 (CDK4) has been found in squamous cell carcinoma of the head and neck (SCCHN), the associations between CDK4 and its regulators, namely, cyclin D1, cyclin E, gankyrin, SEI1, and BMI1 in gene expression remain
Seung Eun Lee et al.
Histology and histopathology, 29(1), 127-138 (2013-07-16)
The amplification of MDM2 and CDK4 is the main molecular feature of well-differentiated liposarcomas (WDLS) and dedifferentiated liposarcomas (DDLS). Although the diagnostic usefulness of this molecular characteristic in liposarcomas has been investigated, its prognostic utility of quantitative gene level has
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