生物来源
chicken
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
种属反应性
mouse, human, rat
制造商/商品名称
Genway 15-288-22317B
技术
western blot: suitable
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... SLP-2(30968)
一般描述
The previously assigned protein identifier Q53G29 has been merged into Q9UJZ1. Full details can be found on the UniProt database.
应用
Anti-SLP-2 (ab2) antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
生化/生理作用
Stomatin-like protein 2 (STOML2) is a member of the stomatin superfamily and is a widely expressed mitochondrial inner membrane protein. It acts as an oncogenic-related protein and is found to be up-regulated in multi-cancers. STOML2 has a role and clinical significance in gastric adenocarcinoma and gallbladder cancer (GBC). Increased expression of STOML2 may lead to unfavorable prognosis for gastric adenocarcinoma patients. STOML2 may play an important role in human GBC tumorigenesis and may serve as a novel prognostic marker in human GBC. It interacts with prohibitin-1 and -2 and binds to the mitochondrial membrane phospholipid cardiolipin. The up-regulation of this gene expression increases cardiolipin content, the formation of metabolically active mitochondrial membranes and also induces mitochondrial biogenesis.
外形
Solution in phosphate buffered saline containing 0.02% sodium azide.
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
新产品
此项目有
Wei-Xin Wang et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 35(1), 419-423 (2013-08-07)
Several studies have indicated that overexpression of stomatin-like protein 2 (SLP-2) has been identified in several types of cancer. However, its role and clinical relevance in gallbladder cancer (GBC) is unknown. The purpose of this study was to reveal the
Xiao-Hong Li et al.
Medical oncology (Northwood, London, England), 31(1), 763-763 (2013-11-22)
Stomatin-like protein 2 (STOML2), a member of the stomatin, has been reported to be upregulated in several human cancers. However, its role and clinical significance in gastric adenocarcinoma remains unclear to date. The purpose of this retrospective study was to
Darah A Christie et al.
Molecular and cellular biology, 31(18), 3845-3856 (2011-07-13)
Stomatin-like protein 2 (SLP-2) is a widely expressed mitochondrial inner membrane protein of unknown function. Here we show that human SLP-2 interacts with prohibitin-1 and -2 and binds to the mitochondrial membrane phospholipid cardiolipin. Upregulation of SLP-2 expression increases cardiolipin
Zhibing Qiu et al.
Journal of cellular biochemistry (2018-10-12)
Previous studies have shown that stomatin-like protein-2 (SLP-2) could regulate mitochondrial biogenesis and function. The study was designed to explore the contribution of SLP-2 to the myocardial ischemia and reperfusion (I/R) injury. Anesthetized rats were treated with SLP-2 and subjected
Wenfeng Cao et al.
PloS one, 8(5), e63890-e63890 (2013-05-15)
Stomatin-like protein 2 (SLP-2), a member of the Stomatin superfamily, has been identified as an oncogenic-related protein and found to be up-regulated in multi-cancers. Nonetheless, the expression pattern and regulation of SLP-2 in human esophageal squamous cell carcinoma (ESCC) remain
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