生物来源
chicken
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
种属反应性
human, mouse, rat
制造商/商品名称
Genway 15-288-22535
技术
western blot: suitable
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
基因信息
human ... EIF3H(8667)
一般描述
EIF3H (eukaryotic translation initiation factor 3, subunit H) is a part of a ~600kDa, multi-protein complex called eIF3, which is made of ten different subunits. This subunit is also called p40. This gene is localized to human chromosome 8q23.3.
免疫原
Immunogen Sequence: GI # 4503515, sequence 1-352
Recombinant eukaryotic translation initiation factor 3, subunit 3 gamma, 40kDa
应用
Anti-EIF353 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
生化/生理作用
EIF3H (eukaryotic translation initiation factor 3, subunit H) is a component of EIF3, which facilitates the binding of methionyl-tRNAi and mRNA, by interacting with 40S ribosome. The up-regulation of this gene leads to elevation in cell proliferation, growth and survival. This gene is amplified in breast and liver cancer. The expression of EIF3H is increased in prostate cancer. It helps in regulating cell growth and viability. Overexpression of the gene may provide growth advantage to the cancer cells.
外形
Solution in phosphate buffered saline containing 0.02% sodium azide.
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储存分类代码
12 - Non Combustible Liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
新产品
此项目有
K J Savinainen et al.
British journal of cancer, 90(5), 1041-1046 (2004-03-05)
The long arm of chromosome 8 is one of the most common regions of amplification in cancers of several organs, especially carcinomas of the breast and prostate. TRPS1, MYC and EIF3S3 genes are located in one of the minimal regions
K Asano et al.
The Journal of biological chemistry, 272(43), 27042-27052 (1997-10-27)
The mammalian translation initiation factor 3 (eIF3), is a multiprotein complex of approximately 600 kDa that binds to the 40 S ribosome and promotes the binding of methionyl-tRNAi and mRNA. cDNAs encoding 5 of the 10 subunits, namely eIF3-p170, -p116
Federico Cappuzzo et al.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 4(4), 472-478 (2009-02-11)
We investigated the incidence of eukaryotic translation initiation factor 3 subunit H (EIF3H) and MYC amplification in non-small cell lung cancer (NSCLC) patients, and whether MYC/EIF3H increased gene copy number affected response to Epidermal Growth Factor Receptor tyrosine kinase inhibitors.
Kimmo J Savinainen et al.
The Prostate, 66(11), 1144-1150 (2006-05-03)
Amplification and overexpression of EIF3S3 gene has been demonstrated in breast and prostate cancer. Here, our goal was to study the effect of EIF3S3 on cell growth. The effect of EIF3S3 on growth of NIH 3T3 murine fibroblasts as well
Alan M Pittman et al.
PLoS genetics, 6(9), e1001126-e1001126 (2010-09-24)
Common genetic variation at human 8q23.3 is significantly associated with colorectal cancer (CRC) risk. To elucidate the basis of this association we compared the frequency of common variants at 8q23.3 in 1,964 CRC cases and 2,081 healthy controls. Reporter gene
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