biological source
chicken
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human, mouse, rat
manufacturer/tradename
Genway 15-288-22535
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... EIF3H(8667)
General description
EIF3H (eukaryotic translation initiation factor 3, subunit H) is a part of a ~600kDa, multi-protein complex called eIF3, which is made of ten different subunits. This subunit is also called p40. This gene is localized to human chromosome 8q23.3.
Immunogen
Immunogen Sequence: GI # 4503515, sequence 1-352
Recombinant eukaryotic translation initiation factor 3, subunit 3 gamma, 40kDa
Application
Anti-EIF353 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biochem/physiol Actions
EIF3H (eukaryotic translation initiation factor 3, subunit H) is a component of EIF3, which facilitates the binding of methionyl-tRNAi and mRNA, by interacting with 40S ribosome. The up-regulation of this gene leads to elevation in cell proliferation, growth and survival. This gene is amplified in breast and liver cancer. The expression of EIF3H is increased in prostate cancer. It helps in regulating cell growth and viability. Overexpression of the gene may provide growth advantage to the cancer cells.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
新产品
此项目有
K J Savinainen et al.
British journal of cancer, 90(5), 1041-1046 (2004-03-05)
The long arm of chromosome 8 is one of the most common regions of amplification in cancers of several organs, especially carcinomas of the breast and prostate. TRPS1, MYC and EIF3S3 genes are located in one of the minimal regions
K Asano et al.
The Journal of biological chemistry, 272(43), 27042-27052 (1997-10-27)
The mammalian translation initiation factor 3 (eIF3), is a multiprotein complex of approximately 600 kDa that binds to the 40 S ribosome and promotes the binding of methionyl-tRNAi and mRNA. cDNAs encoding 5 of the 10 subunits, namely eIF3-p170, -p116
Federico Cappuzzo et al.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 4(4), 472-478 (2009-02-11)
We investigated the incidence of eukaryotic translation initiation factor 3 subunit H (EIF3H) and MYC amplification in non-small cell lung cancer (NSCLC) patients, and whether MYC/EIF3H increased gene copy number affected response to Epidermal Growth Factor Receptor tyrosine kinase inhibitors.
Kimmo J Savinainen et al.
The Prostate, 66(11), 1144-1150 (2006-05-03)
Amplification and overexpression of EIF3S3 gene has been demonstrated in breast and prostate cancer. Here, our goal was to study the effect of EIF3S3 on cell growth. The effect of EIF3S3 on growth of NIH 3T3 murine fibroblasts as well
Alan M Pittman et al.
PLoS genetics, 6(9), e1001126-e1001126 (2010-09-24)
Common genetic variation at human 8q23.3 is significantly associated with colorectal cancer (CRC) risk. To elucidate the basis of this association we compared the frequency of common variants at 8q23.3 in 1,964 CRC cases and 2,081 healthy controls. Reporter gene
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