H127
p-Fluorohexahydro-sila-difenidol hydrochloride
powder, ≥98% (HPLC)
别名:
Cyclohexyl-(4-fluorophenyl)-(3-N-piperidinopropyl)silanol hydrochloride, P-F-HHSiD hydrochloride
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关于此项目
经验公式（希尔记法）:
C20H32FNOSi · HCl
化学文摘社编号:
分子量:
386.02
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
H2O: slightly soluble 1.5 mg/mL
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: >14 mg/mL
ethanol: soluble
SMILES字符串
Cl[H].O[Si](CCCN1CCCCC1)(C2CCCCC2)c3ccc(F)cc3
InChI
1S/C20H32FNOSi.ClH/c21-18-10-12-20(13-11-18)24(23,19-8-3-1-4-9-19)17-7-16-22-14-5-2-6-15-22;/h10-13,19,23H,1-9,14-17H2;1H
InChI key
JMTYYLMGSBSPPK-UHFFFAOYSA-N
基因信息
human ... CHRM3(1131)
应用
p-Fluorohexahydro-sila-difenidol hydrochloride (pFHHSid) has been used:
- as the M3/muscarinic acetylcholine receptor antagonist to study its involvement in carbachol induced Egr-1 biosynthesis using human neuroblastoma cells
- as M3 receptor antagonist to test its involvement on N,N-diethyl-m-toluamide (DEET)-induced angiogenesis in human umbilical venous endothelial cells (HUVEC)
- in a study to examine the role of aclidinium on human fibroblast to myofibroblast
生化/生理作用
High affinity M3 muscarinic acetylcholine receptor antagonist.
特点和优势
This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Frederick J Ehlert et al.
The Journal of pharmacology and experimental therapeutics, 312(2), 592-600 (2004-10-01)
We investigated the ability of the muscarinic antagonist p-fluorohexahydrosiladifenidol to inhibit muscarinic agonist-induced contractions and phosphoinositide hydrolysis in the guinea pig ileum and trachea. This antagonist displayed higher potency at blocking oxotremorine-M-induced contractions of the ileum compared with those of
M T de la Vega et al.
Archives of medical research, 28(4), 493-497 (1997-01-01)
In this study, the authors set out to determine the presence of M3 muscarinic receptors in rat striatum by examining the binding of [3H]N-methylscopolamine ([3H]NMS) to striatal membranes and its displacement by antagonists with different affinity for M1 and M3
Javier Milara et al.
Thorax, 67(3), 229-237 (2011-10-01)
Fibroblast to myofibroblast transition is believed to contribute to airway remodelling in lung diseases such as asthma and chronic obstructive pulmonary disease. This study examines the role of aclidinium, a new long-acting muscarinic antagonist, on human fibroblast to myofibroblast transition.
Oliver G Rössler et al.
Archives of biochemistry and biophysics, 470(1), 93-102 (2007-12-07)
Carbachol-mediated activation of type M(3) muscarinic acetylcholine receptors induces the biosynthesis of the transcription factor Egr-1 in human SH-SY5Y neuroblastoma cells involving an activation of extracellular signal-regulated protein kinase. Carbachol triggered the phosphorylation of the ternary complex factor Elk-1, a
Dora E Benavides-Haro et al.
Naunyn-Schmiedeberg's archives of pharmacology, 368(4), 309-315 (2003-09-10)
The effect of the cholinomimetic agent, bethanechol on macroscopic membrane currents was studied in dispersed cat atrial myocytes, using the whole-cell patch-clamp technique. Bethanechol activated an inward rectifying potassium current similar to I(K(ACh)), and a delayed rectifying-like outward current, similar
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