H127
p-Fluorohexahydro-sila-difenidol hydrochloride
powder, ≥98% (HPLC)
别名:
Cyclohexyl-(4-fluorophenyl)-(3-N-piperidinopropyl)silanol hydrochloride, P-F-HHSiD hydrochloride
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关于此项目
经验公式（希尔记法）:
C20H32FNOSi · HCl
化学文摘社编号:
分子量:
386.02
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI
1S/C20H32FNOSi.ClH/c21-18-10-12-20(13-11-18)24(23,19-8-3-1-4-9-19)17-7-16-22-14-5-2-6-15-22;/h10-13,19,23H,1-9,14-17H2;1H
SMILES string
Cl[H].O[Si](CCCN1CCCCC1)(C2CCCCC2)c3ccc(F)cc3
InChI key
JMTYYLMGSBSPPK-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
H2O: slightly soluble 1.5 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: >14 mg/mL, ethanol: soluble
Quality Level
Gene Information
human ... CHRM3(1131)
Application
p-Fluorohexahydro-sila-difenidol hydrochloride (pFHHSid) has been used:
- as the M3/muscarinic acetylcholine receptor antagonist to study its involvement in carbachol induced Egr-1 biosynthesis using human neuroblastoma cells
- as M3 receptor antagonist to test its involvement on N,N-diethyl-m-toluamide (DEET)-induced angiogenesis in human umbilical venous endothelial cells (HUVEC)
- in a study to examine the role of aclidinium on human fibroblast to myofibroblast
Biochem/physiol Actions
High affinity M3 muscarinic acetylcholine receptor antagonist.
Features and Benefits
This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Frederick J Ehlert et al.
The Journal of pharmacology and experimental therapeutics, 312(2), 592-600 (2004-10-01)
We investigated the ability of the muscarinic antagonist p-fluorohexahydrosiladifenidol to inhibit muscarinic agonist-induced contractions and phosphoinositide hydrolysis in the guinea pig ileum and trachea. This antagonist displayed higher potency at blocking oxotremorine-M-induced contractions of the ileum compared with those of
S M Jankovic et al.
Methods and findings in experimental and clinical pharmacology, 26(2), 87-91 (2004-04-09)
The Fallopian tubes are sparsely innervated with cholinergic nerve fibers. Acetylcholine is released from these nerves and contracts the smooth muscles of the tubes. The aim of our study was to investigate the effect of acetylcholine on the isthmic segment
M R Ruggieri et al.
Autonomic & autacoid pharmacology, 26(3), 311-325 (2006-08-02)
1 The M3 muscarinic receptor subtype is widely accepted as the receptor on smooth muscle cells that mediates cholinergic contraction of the normal urinary bladder and other smooth muscle tissues, however, we have found that the M2 receptor participates in
Slobodan M Jankovic et al.
Pharmacological research, 49(1), 31-35 (2003-11-05)
The Fallopian tubes are scarcely innervated with cholinergic nerve fibers. Acetylcholine released from these nerves contracts smooth muscles of the tubes. The aim of our study was to investigate the effect of acetylcholine on the Fallopian tubes using selective antagonists
Anthony D Miller et al.
The European journal of neuroscience, 21(7), 1837-1846 (2005-05-05)
Laterodorsal (LDT) and pedunculopontine (PPT) tegmental nuclei in the mesopontine project cholinergic inputs to the midbrain ventral tegmental area (VTA) and substantia nigra pars compacta (SNc), respectively, to directly and indirectly influence the activity of dopamine neuronal cells via actions
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