H2519
肝素酶 I 来源于肝素黄杆菌
Lyophilized powder stabilized with approx. 25% bovine serum albumin, ≥200 units/mg protein (enzyme + BSA)
别名:
肝素裂解酶I, 肝素酶
偶联物
conjugate (Glucosaminoglycan)
质量水平
表单
lyophilized solid
比活
≥200 units/mg protein (enzyme + BSA)
分子量
42.8 kDa
应用
diagnostic assay manufacturing
储存温度
−20°C
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应用
来自肝素黄杆菌（Flavobacterium heparinum）的肝素酶I已被用于：
- 消化血浆样品
- 研究培养基、洗涤和超声处理对肺炎衣原体(Chlamydia pneumonia)感染性的影响
- 酶法去除人横纹肌肉瘤细胞表面的硫酸乙酰肝素
生化/生理作用
来自肝素黄杆菌（Flavobacterium heparinum）的肝素酶I通过裂解肝素AT III结合位点处的α-糖苷键而发挥作用。这就产生了小的寡糖碎片。肝素酶 I 可以中和蛋白质的抗凝作用。肝素酶I的半衰期为15-18分钟。
其他说明
在25 °C、pH 7.5条件下，一个单位（Sigma单位）每小时可形成0.1 μ摩尔不饱和糖醛酸。一个国际单位（I.U.）相当于大约600个Sigma单位。
警示用语：
Danger
危险声明
预防措施声明
危险分类
Resp. Sens. 1
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Cardiopulmonary Bypass: Principles and Practice, 509-509 (2008)
Methodological aspects affecting the infectivity of Chlamydia pneumoniae in cell cultures in vitro
Yan Y, et al.
Journal of Microbiological Methods, 61(1), 127-130 (2005)
HeparinHeparin - A Century of Progress, 273-273 (2012)
Wataru Hashimoto et al.
Biochemistry, 53(4), 777-786 (2014-01-21)
Pedobacter heparinus (formerly known as Flavobacterium heparinum) is a typical glycosaminoglycan-degrading bacterium that produces three heparin lyases, Hep I, Hep II, and Hep III, which act on heparins with 1,4-glycoside bonds between uronate and amino sugar residues. Being different from
Udayanath Aich et al.
Analytical chemistry, 83(20), 7815-7822 (2011-08-26)
Heparin and the low molecular weight heparins are extensively used as medicinal products to prevent and treat the formation of venous and arterial thrombi. In early 2008, administration of some heparin lots was associated with the advent of severe adverse
商品
Uncover more about glycosaminoglycans and proteoglycans including the structure of glycosaminoglycans (GAGs), the different types of GAGs, and their functions.
Glycosaminoglycans are large linear polysaccharides constructed of repeating disaccharide units.
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