H2519
肝素酶 I 来源于肝素黄杆菌
Lyophilized powder stabilized with approx. 25% bovine serum albumin, ≥200 units/mg protein (enzyme + BSA)
别名:
肝素裂解酶I, 肝素酶
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关于此项目
化学文摘社编号:
UNSPSC Code:
12352204
NACRES:
NA.54
MDL number:
Specific activity:
≥200 units/mg protein (enzyme + BSA)
产品名称
肝素酶 I 来源于肝素黄杆菌, Lyophilized powder stabilized with approx. 25% bovine serum albumin, ≥200 units/mg protein (enzyme + BSA)
conjugate
conjugate (Glucosaminoglycan)
form
lyophilized solid
specific activity
≥200 units/mg protein (enzyme + BSA)
mol wt
42.8 kDa
application(s)
diagnostic assay manufacturing
storage temp.
−20°C
Quality Level
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Application
来自肝素黄杆菌（Flavobacterium heparinum）的肝素酶I已被用于：
- 消化血浆样品
- 研究培养基、洗涤和超声处理对肺炎衣原体(Chlamydia pneumonia)感染性的影响
- 酶法去除人横纹肌肉瘤细胞表面的硫酸乙酰肝素
Biochem/physiol Actions
来自肝素黄杆菌（Flavobacterium heparinum）的肝素酶I通过裂解肝素AT III结合位点处的α-糖苷键而发挥作用。这就产生了小的寡糖碎片。肝素酶 I 可以中和蛋白质的抗凝作用。肝素酶I的半衰期为15-18分钟。
Other Notes
在25 °C、pH 7.5条件下，一个单位（Sigma单位）每小时可形成0.1 μ摩尔不饱和糖醛酸。一个国际单位（I.U.）相当于大约600个Sigma单位。
signalword
Danger
hcodes
pcodes
Hazard Classifications
Resp. Sens. 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
低风险生物材料
此项目有
Cardiopulmonary Bypass: Principles and Practice, 509-509 (2008)
Methodological aspects affecting the infectivity of Chlamydia pneumoniae in cell cultures in vitro
Yan Y, et al.
Journal of Microbiological Methods, 61(1), 127-130 (2005)
HeparinHeparin - A Century of Progress, 273-273 (2012)
Wataru Hashimoto et al.
Biochemistry, 53(4), 777-786 (2014-01-21)
Pedobacter heparinus (formerly known as Flavobacterium heparinum) is a typical glycosaminoglycan-degrading bacterium that produces three heparin lyases, Hep I, Hep II, and Hep III, which act on heparins with 1,4-glycoside bonds between uronate and amino sugar residues. Being different from
Dong-Ja Kim et al.
The Journal of molecular diagnostics : JMD, 14(1), 71-80 (2011-12-14)
Circulating microRNAs (miRNAs) have emerged as candidate biomarkers of various diseases and conditions including malignancy and pregnancy. This approach requires sensitive and accurate quantitation of miRNA concentrations in body fluids. Herein we report that enzyme-based miRNA quantitation, which is currently
商品
Glycosaminoglycans are large linear polysaccharides constructed of repeating disaccharide units.
Uncover more about glycosaminoglycans and proteoglycans including the structure of glycosaminoglycans (GAGs), the different types of GAGs, and their functions.
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