H3023
20-羟基-（5Z,8Z,11Z,14Z）-二十碳四烯酸
≥90% (HPLC), liquid, Ras/MAP pathway activitor
别名:
20-HETE, 20-羟基花生四烯酸
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关于此项目
经验公式（希尔记法）:
C20H32O3
CAS Number:
分子量:
320.47
MDL编号:
UNSPSC代码:
12352106
PubChem化学物质编号:
NACRES:
NA.77
Product Name
20-羟基-（5Z,8Z,11Z,14Z）-二十碳四烯酸, ~100 μg/mL in ethanol, ≥90% (HPLC)
质量水平
方案
≥90% (HPLC)
表单
liquid
浓度
~100 μg/mL in ethanol
运输
dry ice
储存温度
−20°C
SMILES字符串
OCCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O
InChI
1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10-
InChI key
NNDIXBJHNLFJJP-DTLRTWKJSA-N
相关类别
生化/生理作用
20-羟基-（5Z，8Z，11Z，14Z）-二十碳四烯酸（20-HETE）是通过细胞色素P4504A的花生四烯酸代谢产物，它是Ras/MAP（微管相关蛋白）途径的激活剂。20-HETE酸是肾脏中主要的花生四烯酸。 它参与调节肾小管的钠、钾和氯化物转运。20-HETE通常以葡糖醛酸结合物的形式排泄在尿液中，有时以游离酸的形式排泄。在大鼠妊娠期间观察到尿液20-HETE增加。
包装
在氩气下包装。
警示用语：
Danger
危险声明
危险分类
Eye Irrit. 2 - Flam. Liq. 2
储存分类代码
3 - Flammable liquids
WGK
WGK 1
闪点(°F)
57.2 °F - closed cup
闪点(°C)
14.0 °C - closed cup
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
危险化学品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Lingling Lu et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 39(3), 481-496 (2017-10-27)
Astrocytes express neurotransmitter receptors that serve as sensors of synaptic activity and initiate signals leading to activity-dependent local vasodilation and increases in blood flow. We previously showed that arteriolar vasodilation produced by activation of cortical astrocytes is dependent on endothelial
Kathleen M Lukaszewicz et al.
Clinical science (London, England : 1979), 124(12), 695-700 (2013-02-27)
20-HETE (20-hydroxyeicosatetraenoic acid), a vasoconstrictor metabolite of arachidonic acid formed through the action of CYP4A (cytochrome P450-4A) in vascular smooth muscle cells, has been implicated in the development of hypertension and vascular dysfunction. There have been a number of reports
Tiago J Costa et al.
Frontiers in physiology, 9, 490-490 (2018-06-06)
Postmenopausal period has been associated to different symptoms such as hot flashes, vulvovaginal atrophy, hypoactive sexual desire disorder (HSDD) and others. Clinical studies have described postmenopausal women presenting HSDD can benefit from the association of testosterone to conventional hormonal therapy.
Elevated 12-and 20-hydroxyeicosatetraenoic acid in urine of patients with prostatic diseases
Nithipatikom K, et al.
Cancer Letters, 233(2), 219-225 (2006)
Anne Barden et al.
Free radical biology & medicine, 42(11), 1730-1735 (2007-04-28)
There is considerable evidence that chronic moderate-to-high alcohol consumption increases blood pressure. The mechanisms by which this occurs are not clear. Alcohol consumption can induce oxidative stress and cytochrome P450 (CYP450) isoforms that are associated with oxidative stress and may
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