H5160
贯叶金丝桃素
≥85% (HPLC), Use secondary activity, solution
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关于此项目
经验公式（希尔记法）:
C35H52O4
化学文摘社编号:
分子量:
536.78
EC 号:
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
产品名称
贯叶金丝桃素, ≥85% (HPLC)
质量水平
方案
≥85% (HPLC)
表单
solution
储存温度
−20°C
SMILES字符串
CC(C)C(=O)[C@@]12C(O)=C(C\C=C(\C)C)C(=O)[C@@](C\C=C(/C)C)(C[C@H](C\C=C(\C)C)[C@@]1(C)CC\C=C(\C)C)C2=O
InChI
1S/C35H52O4/c1-22(2)13-12-19-33(11)27(16-14-23(3)4)21-34(20-18-25(7)8)30(37)28(17-15-24(5)6)31(38)35(33,32(34)39)29(36)26(9)10/h13-15,18,26-27,38H,12,16-17,19-21H2,1-11H3/t27-,33+,34+,35-/m0/s1
InChI key
IWBJJCOKGLUQIZ-HQKKAZOISA-N
一般描述
贯叶金丝桃素是圣约翰′草的一种间苯三酚成分，同时也是一种孕烷 X 受体配体。
应用
贯叶金丝桃素可用于：
- 作为参考标准品用于制定高效液相色谱 (HPLC) 分析的校准曲线
- 测试其对小鼠他胚胎细胞的细胞毒性作用和诱导细胞凋亡作用
- 作为猪脑毛细血管内皮细胞孕烷X受体 (PXR) 用于传递检测
生化/生理作用
贯叶金丝桃素是一种活性抗抑郁剂和细胞色素P450 3A4 (CYP3A) 抑制剂。它可诱导抗氧化和抗细菌活性。贯叶金丝桃素还具有胚胎毒性并抑制肿瘤增生。它可有效抑制多巴胺、血清素和去甲肾上腺素。
警示用语：
Danger
危险分类
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
靶器官
Eyes
储存分类代码
3 - Flammable liquids
WGK
WGK 2
闪点(°F)
49.5 °F - closed cup
闪点(°C)
9.7 °C - closed cup
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
危险化学品
此项目有
Murhaf Zaher et al.
International journal of oncology, 40(1), 269-276 (2011-09-29)
We previously reported that hyperforin, a phloroglucinol purified from Hypericum perforatum, induces the mitochondrial pathway of caspase-dependent apoptosis in chronic lymphocytic leukemia (CLL) cells ex vivo, and that this effect is associated with upregulation of Noxa, a BH3-only protein of
Mohamed A Farag et al.
Planta medica, 78(5), 488-496 (2012-01-25)
The growing interest in the efficacy of phytomedicines and herbal supplements but also the increase in legal requirements for safety and reliable contents of active principles drive the development of analytical methods for the quality control of complex, multicomponent mixtures
Determination of hypericin and hyperforin content in selected Jordanian Hypericum species
Tawaha K, et al.
Industrial Crops and Products, 32(3), 241-245 (2010)
L B Moore et al.
Proceedings of the National Academy of Sciences of the United States of America, 97(13), 7500-7502 (2000-06-15)
St. John's wort (Hypericum perforatum) is an herbal remedy used widely for the treatment of depression. Recent clinical studies demonstrate that hypericum extracts increase the metabolism of various drugs, including combined oral contraceptives, cyclosporin, and indinavir. In this report, we
C Billard et al.
Current cancer drug targets, 13(1), 1-10 (2012-08-29)
Hyperforin is a prenylated phloroglucinol present in the medicinal plant St John's wort (Hypericum perforatum). The compound has many biological properties, including antidepressant, anti-inflammatory, antibacterial and antitumor activities. This review focuses on the in vitro antileukemic effects of purified hyperforin
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