Name: Herbimycin A from <I>Streptomyces hygroscopicus</I>
Brand: SIGMA

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About This Item

经验公式（希尔记法）:

C₃₀H₄₂N₂O₉

CAS Number:

70563-58-5

分子量:

574.66

Beilstein:

4834067

MDL编号:

MFCD00151702

UNSPSC代码:

12352200

PubChem化学物质编号:

24895756

NACRES:

NA.77

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生物来源

Streptomyces hygroscopicus

质量水平

200

方案

≥95% (HPLC)

表单

powder

颜色

yellow

溶解性

DMSO: 7.5 mg/mL

抗生素抗菌谱

viruses

作用机制

enzyme | inhibits

储存温度

−20°C

SMILES字符串

CO[C@H]1C[C@H](C)[C@@H](OC)C2=CC(=O)C=C(NC(=O)\C(C)=C\C=C[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1OC)C2=O

InChI

1S/C30H42N2O9/c1-16-10-9-11-23(37-5)28(41-30(31)36)18(3)12-17(2)27(40-8)24(38-6)13-19(4)26(39-7)21-14-20(33)15-22(25(21)34)32-29(16)35/h9-12,14-15,17,19,23-24,26-28H,13H2,1-8H3,(H2,31,36)(H,32,35)/b11-9-,16-10+,18-12+/t17-,19-,23-,24-,26+,27+,28-/m0/s1

InChI key

MCAHMSDENAOJFZ-BVXDHVRPSA-N

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一般描述

DMSO stock solution can be diluted in phosphate buffered saline. The ratio of buffer:DMSO should be greater than 500:1.

Herbimycin A from Streptomyces hygroscopicus is a benzoquinoid ansamycin antibiotic. It is an analog of geldanamycin.

应用

Herbimycin A from Streptomyces hygroscopicus has been used as an inhibitor of Src tyrosine kinase in HEK293T cells and rat intestinal epithelial cells. It has also been used to test its attenuation effect in intimal hyperplasia (IH) post balloon injury in rat carotid artery.

生化/生理作用

An antibiotic that inhibits protein tyrosine kinase. Herbimycin A is a potent inhibitor of angiogenesis.

Herbimycin A is an inducer of heat shock protein (HSP). It increases HSP expression resulting in the attenuation of ischemia reperfusion induced pulmonary injury.