H7270
HC毒素 来源于碳色长蠕孢菌
lyophilized powder
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关于此项目
经验公式（希尔记法）:
C21H32N4O6
化学文摘社编号:
分子量:
436.50
UNSPSC Code:
12352202
PubChem Substance ID:
MDL number:
InChI
1S/C21H32N4O6/c1-12-18(27)22-13(2)19(28)24-14(7-4-3-5-9-16(26)17-11-31-17)21(30)25-10-6-8-15(25)20(29)23-12/h12-15,17H,3-11H2,1-2H3,(H,22,27)(H,23,29)(H,24,28)
SMILES string
CC1NC(=O)C(C)NC(=O)C2CCCN2C(=O)C(CCCCCC(=O)C3CO3)NC1=O
InChI key
GNYCTMYOHGBSBI-UHFFFAOYSA-N
assay
90-95% (TLC)
form
lyophilized powder
storage temp.
2-8°C
Biochem/physiol Actions
Cyclic tetrapeptide fungal toxin selectively toxic to plants with susceptible host genotype.
signalword
Danger
hcodes
pcodes
Hazard Classifications
Acute Tox. 2 Oral
存储类别
6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
J H Ahn et al.
Molecular & general genetics : MGG, 260(5), 462-469 (1999-01-23)
HC-toxin is an epoxide-containing cyclic tetrapeptide that is a critical virulence determinant in the pathogenic interaction between the filamentous fungus Cochliobolus carbonum and maize. HC-toxin exerts a potent cytostatic effect on plant and animal cells by inhibiting histone deacetylase. The
Dipnath Baidyaroy et al.
Eukaryotic cell, 1(4), 538-547 (2002-11-29)
HC-toxin, a cyclic peptide made by the filamentous fungus Cochliobolus carbonum, is an inhibitor of histone deacetylase (HDAC) from many organisms. It was shown earlier that the HDAC activity in crude extracts of C. carbonum is relatively insensitive to HC-toxin
Kyung Nan Min et al.
Archives of pharmacal research, 27(5), 554-561 (2004-06-19)
Trichostatin A, an antifungal antibiotics, and HC-toxin are potent and specific inhibitors of histone deacetylase activity. Histone deacetylase inhibitors are new class of chemotherapeutic drugs able to induce tumor cell apoptosis and/or cell cycle arrest. In this study, the antiproliferative
Y Q Cheng et al.
Journal of natural products, 62(1), 143-145 (1999-01-23)
HC-toxin, cyclo(D-Pro-L-Ala-D-Ala-L-Aeo), where Aeo stands for 2-amino-9,10-epoxi-8-oxodecanoic acid, is a potent inhibitor of histone deacetylase. Previous molecular genetic studies indicated that HC-toxin biosynthesis requires a dedicated fatty acid synthase. The incorporation of [13C]acetate into HC-toxin was studied using NMR. The
J H Ahn et al.
Molecular plant-microbe interactions : MPMI, 10(2), 207-214 (1997-03-01)
The fungal maize pathogen Cochliobolus carbonum produces a phytotoxic and cytostatic cyclic peptide, HC-toxin, of structure cyclo(D-prolyl-L-alanyl-D-alanyl-L-Aeo), in which Aeo stands for 2-amino-9,10-epoxi-8-oxodecanoic acid. Here we report the isolation of a gene, TOXC, that is present only in HC-toxin-producing (Tox2+)
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