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Merck
CN

H8891

Sigma-Aldrich

肝素酶III 来源于肝素黄杆菌

Lyophilized powder stabilized with approx. 25% (w/w) bovine serum albumin, ≥30 units/mg protein (enzyme + BSA)

别名:

肝素裂解酶III, 肝素酶 来源于肝素黄杆菌, 肝素酶I

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关于此项目

CAS Number:
37290-86-1
EC 号:
4.2.2.8 (BRENDA, IUBMB)
MDL编号:
MFCD00131319
UNSPSC代码:
12352204
NACRES:
NA.54

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生物来源

bacterial (Flavobacterium heparinum)

质量水平

200

偶联物

conjugate (Glucosaminoglycan)

表单

lyophilized powder

比活

≥30 units/mg protein (enzyme + BSA)

分子量

70.8 kDa

应用

diagnostic assay manufacturing

储存温度

−20°C

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相关类别

应用

肝素黄杆菌肝素酶III已用于裂解特定GAG。已用于研究其对与抗aFGF（酸性成纤维细胞生长因子）抗体反应的蛋白质的电泳迁移率的影响。

生化/生理作用

肝素酶III可防止体内新血管的形成。它在HNY-I和HNY、6X-G2连接处特异性降解硫酸肝素。与其他肝素酶不同，肝素酶III不含氨基酸半胱氨酸。它含有13个组氨酸残基，这是其催化作用的原因。该酶对肝素或低分子量肝素没有活性。
肝素降解裂解酶，识别硫酸肝素蛋白聚糖为其主要底物。

其他说明

在25 °C、pH 7.5条件下，一个单位每小时可形成0.1 μM不饱和糖醛酸。一个国际单位（I.U.）相当于大约600个Sigma单位。包装规格基于Sigma单位。
更多关于复杂碳水化合物分析酶的信息请见www.sigma-aldrich.com/enzymeexplorer

象形图

Health hazard
GHS08

警示用语：

Danger

危险声明

H334

预防措施声明

P261 - P284 - P501

危险分类

Resp. Sens. 1

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

常规特殊物品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000440447
0000440447
0000439736
0000439735
0000439735

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. Is Product No. H8891, Heparinase III sold based on Sigma Units or International Units?

    This material is sold based on Sigma Units.  One Sigma Unit will form 0.1 μmole of unsaturated uronic acid per hr at pH 7.5 at 25 °C. One International Unit (I.U.) is equivalent to approx. 600 Sigma units.  

  6. Does Product No. H8891, Heparinase III, contain calcium?

    This product is lyophilized from a solution which is 75 mM NaCl/ 5mM NaH2PO4. We have no reason to believe that calcium ions are present.

  7. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

A Constantinescu et al.
Thrombosis and haemostasis, 105(5), 790-801 (2010-12-22)
A thick endothelial glycocalyx contributes to the barrier function of vascular endothelium in macro- and microcirculation. We hypothesised in the current study that diet-induced hyperlipidaemia perturbs the glycocalyx, resulting in decreased dimensions of this layer and increased transendothelial lipoprotein leakage
Composition of the endothelial glycocalyx and its relation to its thickness and diffusion of small solutes
Gao L and Lipowsky HH
Microvascular Research, 80(3), 394-401 (2010)
Andrea Garolla et al.
Human reproduction (Oxford, England), 27(4), 967-973 (2012-02-09)
Human papillomavirus (HPV) infection has been demonstrated in the sperm of a large percentage of sexually active males and is associated with an impairment of sperm parameters, with a particular negative impact on sperm motility, suggesting a possible role in
FGF binding by extracellular matrix components of Wharton's jelly
Malkowski A, et al.
Acta Biochimica Polonica, 54(2), 357-357 (2007)
Fluid shear stress primes mouse embryonic stem cells for differentiation in a self-renewing environment via heparan sulfate proteoglycans transduction
Toh YC and Voldman J
Faseb Journal, 25(4), 1208-1217 (2011)
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