H9633
L-同型半胱氨酸
≥98% (TLC)
别名:
L-2-氨基-4-磺基丁酸
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关于此项目
经验公式（希尔记法）:
C4H9NO5S
CAS Number:
分子量:
183.18
MDL编号:
UNSPSC代码:
12352106
PubChem化学物质编号:
NACRES:
NA.32
Product Name
L-同型半胱氨酸, ≥95%
质量水平
方案
≥95%
≥98% (TLC)
表单
powder
颜色
white to off-white
应用
cell analysis
SMILES字符串
N[C@@H](CCS(O)(=O)=O)C(O)=O
InChI
1S/C4H9NO5S/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H,8,9,10)/t3-/m0/s1
InChI key
VBOQYPQEPHKASR-VKHMYHEASA-N
相关类别
应用
L-同型半胱氨酸已被用于研究在神经系统中过氧化氢介导的生理和病理状态变化。
生化/生理作用
L-同型半胱氨酸（L-HCA）是NMDA（N-甲基-D-天冬氨酸）受体的一种内源性神经递质配体。它是谷氨酸的一种类似物，可竞争性抑制神经元中谷氨酸-半胱氨酸（xc-）反转运蛋白的功能，引起半胱氨酸摄取量下降。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Hari H Subramanian et al.
The Journal of comparative neurology, 526(2), 229-242 (2017-09-07)
The nucleus retroambiguus (NRA) is a neuronal cell group in the medullary ventrolateral tegmentum, rostrocaudally between the obex and the first cervical spinal segment. NRA neurons are premotor interneurons with direct projections to the motoneurons of soft palate, pharynx, and
M Piraud et al.
Rapid communications in mass spectrometry : RCM, 19(22), 3287-3297 (2005-10-20)
Seventy-six compounds of biological interest for the diagnosis of inherited disorders of amino acids (AA) metabolism have previously been demonstrated to be detectable in positive mode electrospray ionisation tandem mass spectrometry (ESI-MS/MS), after separation by ion-pairing reversed-phase liquid chromatography (RPLC).
R Gurke et al.
Journal of pharmaceutical and biomedical analysis, 174, 578-587 (2019-07-02)
The role of homocysteic acid (HCA) in severe diseases like Alzheimer's disease is under discussion and some recent studies correlate elevated HCA concentrations with the diagnosis of Alzheimer's. However, non-selective and insufficiently sensitive methods have been used to quantitate HCA
T Knöpfel et al.
Neuroscience letters, 81(1-2), 188-192 (1987-10-16)
The effects of ionophoretically applied L-homocysteate (L-HCA), L-glutamate (L-Glu) and N-methyl-D-aspartate (NMDA) were compared in rat neocortical neurons recorded intracellularly in vitro. The firing pattern and the time course of membrane depolarization induced by L-HCA resembled those of NMDA responses.
J W Olney et al.
Brain research bulletin, 19(5), 597-602 (1987-11-01)
L-Homocysteic acid (L-HCA) has been proposed as a natural transmitter at the N-methyl-D-aspartate (NMDA) subtype of excitatory amino acid receptor based on recent evidence that L-HCA occurs L-HCA occurs naturally in the mammalian CNS, is released from K+ stimulated brain
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