Lot specific orders are not able to be placed through the web. Contact your local sales rep for more details. Human hepatic Sinusoidal Endothelial cells (HSECs) are specialized endothelial cells in the liver that participate in the receptor-mediated clearance of endotoxin, bacteria, and other compounds. HSECs are also known to regulate inflammation, leukocyte recruitment, and host-immune responses to invading pathogens. Human HSECs are a valuable tool for the study of liver physiology and pathophysiology in vitro.

Human hepatic sinusoidal endothelial cells are ideal in studies of: chronic liver injury, toxicity, immune response, portal vein fibrosis, angiogenesis, liver regeneration, stellate cell activation and more. We offer matched sets of sinusoidal endothelial cells from same donor as Hepatocytes, which can be used for co-culture systems to better simulate the complex microenvironment of the liver and gain insights into various liver-related diseases and conditions.

Our collection of hepatic Sinusoidal Endothelial cells is isolated through collagenase digestion and selective cell culture media. Our frozen HSECs are cryopreserved at the end of the primary culture. Each lot undergoes testing for specific cell markers and comes with a guarantee of ≥70% post-thaw viability. In addition, all cells have been tested for the absence of HIV, HBV, HCV, Syphillis and microbial contaminants (fungi, bacteria, and mycoplasma).

Each donor is tested and found non-reactive to viral DNA from HIV-1, HIV-2, HTLV I, HTLV II, hepatitis B and hepatitis C. However, no known test can offer complete assurance that the viruses that cause HIV-1, HIV-2, HTLV I, HTLV II, hepatitis B and hepatitis C are not present. Proper precautions and biological containment should be taken when handling cells of human origin, due to their potential biohazardous nature. All human based products should be handled at a BSL-2 (Biosafety Level 2) or higher.

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.