Anti-SHANK2 antibody produced in rabbit

SHANK2 (SH3 and multiple ankyrin repeat domains 2) gene encodes a scaffold protein belonging to the Shank family of synaptic proteins. The Shank proteins contain multiple ankyrin repeats, an SH3 domain, a PDZ domain, a long proline-rich region that spans more than half the protein, and a sterile α motif (SAM) domain. This family includes SHANK1, SHANK2 and SHANK3, all of which localize to postsynaptic sites of excitatory synapses in the brain. SHANK2 protein lacks the ankyrin repeat.

SH3 and multiple ankyrin repeat domains protein 2 recombinant protein epitope signature tag (PrEST)

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

SH3 and multiple ankyrin repeat domains 2 (SHANK2) protein is a multimodular scaffold protein present in the postsynaptic density (PSD). The PDZ domain of SHANK2 interacts with the C terminus of Phospholipase-β3 and brings it closer to Homer 1b for the regulation of mGluR-mediated calcium signal in the PSD region of neuronal synapses. Mutations in this gene have been linked to autism spectrum disorder and mental retardation.

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

Corresponding Antigen APREST71536.

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.