Anti-INHBA antibody produced in rabbit

INHBA (Inhibin, β A) is a morphogen belonging to the TGFβ superfamily. It encodes a protein reffered to as activin A. It is expressed in both α- and β-cells of pancreatic islets. It is composed of two nearly anti-parallel activin A monomers separated by a 2-fold symmetry axis. Each monomer consists of the canonical TGF-β fold.

Inhibin beta A chain Precursor recombinant protein epitope signature tag (PrEST)

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)

INHBA (Inhibin, β A) is associated with various cellular activities such as cell differentiation, proliferation, activation and apoptosis. It has binding affinity for both the type I and type II serine/threonine kinase receptors. INHBA directly binds to the extracellular domain of the type II receptor, ActRIIB, which further adhere to the outer edges of the activin finger regions. It controls genetic expression of islet β cells. In non-small cell lung cancer (NSCLC), it acts as an autocrine factor in the maintenance of mesenchymal properties of cancer-initiating cells (CICs) to promote metastasis.

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

Corresponding Antigen APREST84518.

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.