生物来源
human
重组
expressed in E. coli
方案
>97% (SDS-PAGE)
表单
lyophilized powder
效能
30-60 ng/mL ED50
分子量
8.5 kDa
储存条件
avoid repeated freeze/thaw cycles (Storage in "frost-free" freezers is not recommended)
技术
cell culture | mammalian: suitable
杂质
endotoxin, tested
UniProt登记号
储存温度
−20°C
基因信息
human ... CCL1(6346)
生化/生理作用
I-309, a chemoattractant for monocytes but not neutrophils, is an approximately 8.5 kDa polypeptide of 73 amino acids. Human I-309 is thought to be a homolog of the mouse TCA3, and shows 42% amino acid homology to mouse TCA3.
I-309, a glycoprotein, is a chemoattractant for monocytes. It is secreted by monocytes, activated macrophages and T lymphocytes. Presence of I-309 in lymph node lymphatic sinuses controls metastases into the lymph nodes. It suppresses CCR8 (C-C motif chemokine receptor 8)-induced HIV (human immunodeficiency virus) infection and also participates in angiogenesis. I-309 is also referred to as CCL1 (C-C motif chemokine ligand 1).
外形
Lyophilized from 30% acetonitrile and 0.1% trifluoroacetic acid containing 0.5 mg bovine serum albumin.
分析说明
Bioactivity measured by ability of I-309 to chemoattract hCCR8 transfected BaF/3 cells.
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Inhalation - Eye Irrit. 2
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Suvendu Das et al.
The Journal of experimental medicine, 210(8), 1509-1528 (2013-07-24)
Lymphatic vessels are thought to contribute to metastasis primarily by serving as a transportation system. It is widely believed that tumor cells enter lymph nodes passively by the flow of lymph. We demonstrate that lymph node lymphatic sinuses control tumor
Rita Crinelli et al.
Antioxidants (Basel, Switzerland), 10(2) (2021-02-04)
I-152 combines two pro-glutathione (GSH) molecules, namely N-acetyl-cysteine (NAC) and cysteamine (MEA), to improve their potency. The co-drug efficiently increases/replenishes GSH levels in vitro and in vivo; little is known about its mechanism of action. Here we demonstrate that I-152
M D Miller et al.
Proceedings of the National Academy of Sciences of the United States of America, 89(7), 2950-2954 (1992-04-01)
The human cytokine I-309 is a small glycoprotein secreted by activated T lymphocytes and structurally related to a number of inflammatory cytokines. To investigate the biological activities of I-309 protein, we produced a stable Chinese hamster ovary cell transfectant, CDI.10
M D Miller et al.
Journal of immunology (Baltimore, Md. : 1950), 143(9), 2907-2916 (1989-11-01)
We have identified two cDNA clones, I-309 and G-26, which define genes expressed abundantly in activated human PBMC, but at low or undetectable levels in resting PBMC. Based upon nucleotide sequence analysis, both clones are predicted to encode small, structurally
Catherine Denis et al.
PloS one, 7(3), e34199-e34199 (2012-04-06)
Carboxypeptidase M (CPM) targets the basic amino acids arginine and lysine present at the C-terminus of peptides or proteins. CPM is thought to be involved in inflammatory processes. This is corroborated by CPM-mediated trimming and modulation of inflammatory factors, and
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