I2002
异柠檬脱氢酶 (NADP) 来源于猪心脏
Type IV, buffered aqueous glycerol solution, 3-20 units/mg protein
别名:
ICDH, IDH, 苏式-Ds-异柠檬酸: NADP+ 氧化还原酶
应用
异柠檬酸脱氢酶（IDH）已用于：
- 体外活性测定，用于研究钍对线粒体呼吸途径中柠檬酸循环酶的影响
- 作为测量温度对烟酰胺二磷酸（NADP）-IDH 活性影响的标准品
- 异柠檬酸盐含量测定
生化/生理作用
异柠檬酸脱氢酶（IDH）是一种同源二聚酶，参与适应缺氧、组蛋白去甲基化和 DNA 修饰等一些过程。这种酶有三种异构体，如 IDH1、IDH2 和 IDH3。
外形
50%甘油EDTA缓冲盐溶液，pH 6.0
其他说明
在37℃条件下，当pH为7.4时，一个单位每分钟将1.0 μ摩尔的异柠檬酸盐转化为至α-酮戊二酸。
储存分类代码
10 - Combustible liquids
WGK
WGK 2
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
动植物源性产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Erdem M Terzi et al.
Science advances, 7(22) (2021-05-28)
Intracellular iron levels are strictly regulated to support homeostasis and avoid iron-mediated ROS production. Loss of iron-sulfur cluster (ISC) synthesis can increase iron loading and promote cell death by ferroptosis. Iron-responsive element-binding proteins IRP1 and IRP2 posttranscriptionally regulate iron homeostasis.
Sergiy M Nadtochiy et al.
The Journal of biological chemistry, 291(38), 20188-20197 (2016-08-12)
2-Hydroxyglutarate (2-HG) is an important epigenetic regulator, with potential roles in cancer and stem cell biology. The d-(R)-enantiomer (d-2-HG) is an oncometabolite generated from α-ketoglutarate (α-KG) by mutant isocitrate dehydrogenase, whereas l-(S)-2-HG is generated by lactate dehydrogenase and malate dehydrogenase
Icksoo Lee et al.
Biochimica et biophysica acta, 1802(2), 275-283 (2009-10-20)
Noonan syndrome (NS) is an autosomal dominant disorder, and a main feature is congenital heart malformation. About 50% of cases are caused by gain-of-function mutations in the tyrosine phosphatase SHP2/PTPN11, a downstream regulator of ERK/MAPK. Recently it was reported that
Avtar Singh et al.
The Journal of biological chemistry, 278(35), 33208-33216 (2003-06-07)
Transhydrogenase couples the reduction of NADP+ by NADH to inward proton translocation across mitochondrial and bacterial membranes. The coupling reactions occur within the protein by long distance conformational changes. In intact transhydrogenase and in complexes formed from the isolated, nucleotide-binding
M Ryan Smith et al.
Redox biology, 8, 136-148 (2016-01-18)
Many cancer cells follow an aberrant metabolic program to maintain energy for rapid cell proliferation. Metabolic reprogramming often involves the upregulation of glutaminolysis to generate reducing equivalents for the electron transport chain and amino acids for protein synthesis. Critical enzymes
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持