I4632
2-亚氨基生物素
≥98% (TLC)
别名:
六氢-2-亚氨基-1H-噻吩 [3,4-d] 咪唑-4-戊酸, 胍基生物素
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关于此项目
经验公式（希尔记法）:
C10H17N3O2S
化学文摘社编号:
分子量:
243.33
UNSPSC Code:
12352203
NACRES:
NA.46
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
18952
产品名称
2-亚氨基生物素, ≥98% (TLC)
InChI
1S/C10H17N3O2S/c11-10-12-6-5-16-7(9(6)13-10)3-1-2-4-8(14)15/h6-7,9H,1-5H2,(H,14,15)(H3,11,12,13)/t6-,7-,9-/m0/s1
SMILES string
[H][C@]12CS[C@@H](CCCCC(O)=O)[C@@]1([H])NC(=N)N2
InChI key
WWVANQJRLPIHNS-ZKWXMUAHSA-N
biological source
synthetic (organic)
assay
≥98% (TLC)
form
powder
solubility
1 M HCl: 50 mg/mL, clear, colorless
storage temp.
2-8°C
Quality Level
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相关类别
Application
已将 2-亚氨基生物素用作竞争性抑制剂，与链霉亲和素的生物结合位点结合，以恢复荧光信号。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
2-亚氨基生物素是生物素的环状胍基类似物，在高 pH (> 9) 下对亲和素具有高亲和力，在低 pH (< 6) 下具有低亲和力。亚氨基生物素化的蛋白质选择性地包含在 pH 9-11 的亲和素柱内，可在 pH 4 洗脱或加入生物素洗脱。该技术可用于研究细胞表面蛋白，通过标记和选择性地从完整的人红细胞表面回收高碘酸盐敏感的成分。2-亚氨基生物素通过其胍基可逆性抑制 NOS（一氧化氮合酶）。它抑制 NO 的生物合成，了解这类重要酶的结合位点相互作用可能很重要。NOS 氧化 L-精氨酸的胍基氮生成一氧化氮和 L-瓜氨酸。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Tijen Utkan et al.
Pharmacology, biochemistry, and behavior, 101(4), 515-519 (2012-03-13)
The aim of this study was to compare the effects of both neuronal NOS (nNOS) and inducible NOS (iNOS) inhibitor 2-iminobiotin, with the more selective nNOS inhibitor N(ω)-propyl-L-arginine (NPLA) and selective inducible NOS (iNOS) inhibitor aminoguanidine, on emotional learning, working
Hiroyuki Inoue et al.
Biomacromolecules, 6(1), 27-29 (2005-01-11)
A layer-by-layer thin film composed of avidin and 2-iminobiotin-labeled poly(ethyleneimine) (ib-PEI) was prepared and their sensitivity to the environmental pH and biotin was studied. The avidin/ib-PEI multilayer assemblies were stable at pH 8-12, whereas the assemblies were decomposed at pH
Katsuhiko Sato et al.
Journal of colloid and interface science, 315(1), 396-399 (2007-07-17)
The effects of hydrogen peroxide on the electrochemical decomposition of layer-by-layer thin films composed of 2-iminobiotin-labeled poly(ethyleneimine) (ib-PEI) and avidin were studied. An ib-PEI/avidin thin film prepared on the surface of a platinum (Pt) film-coated quartz resonator was electrochemically decomposed
F K Athappilly et al.
Protein science : a publication of the Protein Society, 6(6), 1338-1342 (1997-06-01)
Streptavidin binds 2'-iminobiotin in a pH-dependent fashion--affinity decreases as the pH is lowered. This property makes the purification of compounds conjugated to streptavidin or immobiotin possible under mild conditions by affinity chromatography. In order to understand the molecular details of
Cacha Peeters-Scholte et al.
Experimental brain research, 156(1), 20-26 (2003-12-23)
Early detection of delayed cerebral energy failure may be important in the prevention of reperfusion injury of the brain after severe perinatal hypoxia-ischaemia (HI). This study investigated whether monitoring of the redox state of cytochrome aa(3) (Cytaa(3)) with near infrared
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