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I5514

D-myo-Inositol 1,4,5,6-tetrakis(phosphate) potassium salt

Name: <SC>D</SC>-<I>myo</I>-Inositol 1,4,5,6-tetrakis(phosphate) potassium salt
Brand: SIGMA

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关于此项目

线性分子式:

C₆H₈O₁₈P₄K₈

化学文摘社编号:

103497-71-8

分子量:

804.80

UNSPSC Code:

12352201

PubChem Substance ID:

329815385

MDL number:

MFCD02684406

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属性

storage temp.

−20°C

SMILES string

[K+].[K+].[K+].[K+].[K+].[K+].[K+].[K+].O[C@@H]1[C@H](O)[C@@H](OP([O-])([O-])=O)[C@H](OP([O-])([O-])=O)[C@@H](OP([O-])([O-])=O)[C@@H]1OP([O-])([O-])=O

InChI

1S/C6H16O18P4.8K/c7-1-2(8)4(22-26(12,13)14)6(24-28(18,19)20)5(23-27(15,16)17)3(1)21-25(9,10)11;;;;;;;;/h1-8H,(H2,9,10,11)(H2,12,13,14)(H2,15,16,17)(H2,18,19,20);;;;;;;;/q;8*+1/p-8/t1-,2+,3-,4-,5+,6+;;;;;;;;/m1......../s1

InChI key

KOARMWMDZTZZSB-FPQWBLQBSA-F

说明

Biochem/physiol Actions

Component of lipid signaling pathway; shown to antagonize the negative regulation of calcium-mediated chloride secretion by epidermal growth factor; also shown to bind to pleckstrin homology (PH) domain of p130

存储类别

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

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Localization of a high-affinity inositol 1,4,5-trisphosphate/inositol 1,4,5,6-tetrakisphosphate binding domain to the pleckstrin homology module of a new 130 kDa protein: characterization of the determinants of structural specificity.

H Takeuchi et al.

The Biochemical journal, 318 ( Pt 2), 561-568 (1996-09-01)

We have previously identified a novel 130 kDa protein (p130) which binds Ins(1,4,5)P3 and shares 38% sequence identity with phospholipase C-delta 1 [Kanematsu, Misumi, Watanabe, Ozaki, Koga, Iwanaga, Ikehara and Hirata (1996) Biochem. J. 313, 319-325]. We have now transfected

The versatility of inositol phosphates as cellular signals.

S B Shears

Biochimica et biophysica acta, 1436(1-2), 49-67 (1998-12-05)

Cells from across the phylogenetic spectrum contain a variety of inositol phosphates. Many different functions have been ascribed to this group of compounds. However, it is remarkable how frequently several of these different inositol phosphates have been linked to various

D-myo-Inositol 1,4,5,6-tetrakisphosphate produced in human intestinal epithelial cells in response to Salmonella invasion inhibits phosphoinositide 3-kinase signaling pathways.

L Eckmann et al.

Proceedings of the National Academy of Sciences of the United States of America, 94(26), 14456-14460 (1998-02-07)

Several inositol-containing compounds play key roles in receptor-mediated cell signaling events. Here, we describe a function for a specific inositol polyphosphate, D-myo-inositol 1,4,5,6-tetrakisphosphate [Ins(1,4,5,6)P4], that is produced acutely in response to a receptor-independent process. Thus, infection of intestinal epithelial cells