drug control
USDEA Schedule I; regulated under CDSA - not available from Sigma-Aldrich Canada
solubility
H2O: soluble, methanol: soluble
application(s)
forensics and toxicology
SMILES string
Cl.CCC1CC2CC3C1N(CCc4c3[nH]c5ccc(OC)cc45)C2
Biochem/physiol Actions
CNS stimulant and hallucinogen; anti-convulsant.
Ibogaine is a central nervous system stimulant and hallucinogen that has been reported to be a σ2 agonist, a noncompetitive NMDA receptor antagonist at the phencyclidine site and an enhancer of purinergic muscle contractions. It is also a competitive inhibitor of serotonin and dopamine transport. It is an anti-convulsant and has anti-addictive properties against cocaine and heroin.
Preparation Note
Alkaloid isolated from the African shrub, Tabernanthe iboga.
