drug control
USDEA Schedule I; regulated under CDSA - not available from Sigma-Aldrich Canada
solubility
H2O: soluble, methanol: soluble
application(s)
forensics and toxicology
SMILES string
Cl.CCC1CC2CC3C1N(CCc4c3[nH]c5ccc(OC)cc45)C2
Biochem/physiol Actions
CNS stimulant and hallucinogen; anti-convulsant.
Ibogaine is a central nervous system stimulant and hallucinogen that has been reported to be a σ2 agonist, a noncompetitive NMDA receptor antagonist at the phencyclidine site and an enhancer of purinergic muscle contractions. It is also a competitive inhibitor of serotonin and dopamine transport. It is an anti-convulsant and has anti-addictive properties against cocaine and heroin.
Preparation Note
Alkaloid isolated from the African shrub, Tabernanthe iboga.
K K Szumlinski et al.
Pharmacology, biochemistry, and behavior, 63(3), 457-464 (1999-07-27)
Pretreatment (19 h) with the putative antiaddictive agent, ibogaine, has been shown previously to potentiate cocaine-induced locomotion in rats. The present study demonstrates that the magnitude of this effect of ibogaine is dependent on the previous cocaine history of the
Y Itzhak et al.
Annals of the New York Academy of Sciences, 844, 245-251 (1998-07-21)
Although the alkaloid ibogaine is a potent hallucinogenic agent some indications suggest that it may be useful for the treatment of opioid and cocaine addiction. The neurochemical mechanism(s) underlying ibogaine effects remain unclear. In the present study we investigated the
S D Glick et al.
Annals of the New York Academy of Sciences, 909, 88-103 (2000-07-27)
Ibogaine, one of several alkaloids found in the root bark of the African shrub Tabernanthe iboga, has been claimed to be effective in treating multiple forms of drug abuse. Problems associated with side effects of ibogaine have spawned a search