I9910
Ibutilide hemifumarate salt
≥98% (HPLC), Class III antiarrhythmic agent, solid
别名:
(±)-N-[4-[4-(Ethylheptylamino)-1-hydroxybutyl]phenyl]-methanesulfonamide hemifumarate salt, Corvert
登录查看公司和协议定价
选择尺寸
关于此项目
经验公式（希尔记法）:
C20H36N2O3S · 0.5C4H4O4
化学文摘社编号:
分子量:
442.61
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
产品名称
Ibutilide hemifumarate salt, ≥98% (HPLC)
质量水平
方案
≥98% (HPLC)
表单
solid
颜色
off-white to tan
溶解性
H2O: >20 mg/mL
储存温度
room temp
SMILES字符串
OC(=O)\C=C\C(O)=O.CCCCCCCN(CC)CCCC(O)c1ccc(NS(C)(=O)=O)cc1.CCCCCCCN(CC)CCCC(O)c2ccc(NS(C)(=O)=O)cc2
InChI
1S/2C20H36N2O3S.C4H4O4/c2*1-4-6-7-8-9-16-22(5-2)17-10-11-20(23)18-12-14-19(15-13-18)21-26(3,24)25;5-3(6)1-2-4(7)8/h2*12-15,20-21,23H,4-11,16-17H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;;2-1+
InChI key
PCIOHQNIRPWFMV-WXXKFALUSA-N
基因信息
human ... KCNH2(3757)
正在寻找类似产品? 访问 产品对比指南
生化/生理作用
Ibutilide hemifumarate salt is considered a new generation "pure" Class III antiarrhythmic agent.
Ibutilide hemifumarate salt is considered a new generation "pure" Class III antiarrhythmic agent. Ibutilide binds to and alters the activity of hERG potassium channels, delayed inward rectifier potassium (IKr) channels and L-type (dihydropyridine sensitive) calcium channels.
特点和优势
This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral - Repr. 2
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
James E Tisdale et al.
Journal of clinical pharmacology, 52(9), 1296-1305 (2011-11-03)
Patients with heart failure (HF) are at increased risk for drug-induced torsades de pointes (TdP) due to unknown mechanisms. Our objective was to determine if sensitivity to drug-induced QT interval lengthening is enhanced in patients with HF. In this multicenter
Madhuri Nair et al.
Journal of the American Board of Family Medicine : JABFM, 24(1), 86-92 (2011-01-07)
This article reviews the safety and efficacy of ibutilide for use in patients with atrial fibrillation and flutter. Ibutilide, a class III antiarrhythmic agent, is primarily used for conversion of atrial flutter and fibrillation and is a good alternative to
Prince J Kannankeril et al.
Heart rhythm, 8(10), 1530-1534 (2011-03-23)
The degree of QT prolongation by drug is highly variable and related to risk for polymorphic ventricular tachycardia due to drugs. The purpose of this study was to determine factors that affect the degree of QT prolongation by drugs. QT
Michael M Hirschl et al.
The American journal of emergency medicine, 29(5), 534-540 (2010-09-10)
Pharmacologic cardioversion of atrial fibrillation (AF) is a reasonable mode of treatment if the arrhythmia is of recent onset. Results concerning the response rates of different drugs, respectively, in daily clinical practice and data with regard to the parameters associated
Sotirios Patsilinakos et al.
The American journal of cardiology, 106(5), 673-676 (2010-08-21)
Ibutilide is a class III antiarrhythmic agent indicated for cardioversion of atrial fibrillation and atrial flutter to sinus rhythm (SR). The most serious complication of ibutilide is torsades de pointes (TdP). Magnesium has been successfully used for the treatment of
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持