J3774
Monoclonal Anti-JAK1 antibody produced in mouse
2 mg/mL, clone JAK1-193, purified immunoglobulin, buffered aqueous solution
别名:
Anti-Janus Kinase 1
生物来源
mouse
偶联物
unconjugated
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
JAK1-193, monoclonal
表单
buffered aqueous solution
分子量
antigen 130 kDa
种属反应性
rat, human, mouse
浓度
2 mg/mL
技术
indirect ELISA: suitable
microarray: suitable
western blot: 2-4 μg/mL using extract from Raji cells
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... JAK1(3716)
mouse ... Jak1(16451)
rat ... Jak1(84598)
一般描述
The Janus kinases (JAKs) are protein tyrosine kinases that modulate cytokine signaling during immunological responses and hematopoiesis. JAK family members consist of four isoforms, namely, JAK1, JAK2, JAK3 and TYK2. JAK1 plays a crucial role in mediating the JAK/STAT signaling response to interleukin 6. Alterations in JAK functions have been implicated in heart and immunological disorders, as well as in hematopoietic malignancies . Monoclonal Anti-JAK1 antibody is specific for human JAK1 (approx. 130 kDa).
免疫原
The peptide sequence is identical in mouse and rat JAK1.
synthetic peptide corresponding to amino acids 543-555 of human JAK1, conjugated to KLH
应用
Monoclonal Anti-JAK1 antibody is suitable for use in western blot (2-4 μg/mL using extract from Raji cells), indirect ELISA and microarray.
外形
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium aside.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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D Guschin et al.
The EMBO journal, 14(7), 1421-1429 (1995-04-03)
The protein tyrosine kinases JAK1, JAK2 and Tyk2 and STATs (signal transducers and activators of transcription) 1 and 3 are activated in response to interleukin-6 (IL-6) in human fibrosarcoma cells. In mutant cells lacking JAK1, JAK2 or Tyk2, the absence
Neal K Williams et al.
Journal of molecular biology, 387(1), 219-232 (2009-04-14)
The Janus kinases (JAKs) are a pivotal family of protein tyrosine kinases (PTKs) that play prominent roles in numerous cytokine signaling pathways, with aberrant JAK activity associated with a variety of hematopoietic malignancies, cardiovascular diseases and immune-related disorders. Whereas the
William Vainchenker et al.
Seminars in cell & developmental biology, 19(4), 385-393 (2008-08-07)
The four mammalian Janus kinase (JAK) family members, JAK1, JAK2, JAK3 and TYK2, are non-receptor protein tyrosine kinases (PTKs) that are crucial for cytokine receptor signaling in blood formation and immune responses. Mutations and translocations in the JAK genes leading
Hui Shang et al.
Journal of biochemical and molecular toxicology, 35(10), e22882-e22882 (2021-09-25)
Human cervical cancer is the fourth most common carcinoma in women in the world. The JAK/STAT3 signaling pathways crucially regulate cell growth and apoptosis. It is a significant target signaling pathway for the development of novel antitumor medicine. This study
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