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Merck
CN

K1507

Kirromycin from Streptomyces collinus

别名:

Antibiotic Myc-8003, Mocimycin

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关于此项目

经验公式（希尔记法）:
C43H60N2O12
化学文摘社编号:
50935-71-2
分子量:
796.94
NACRES:
NA.85
PubChem Substance ID:
24896207
UNSPSC Code:
51102829
EC Number:
256-859-9
MDL number:
MFCD00467139

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InChI key

HMSYAPGFKGSXAJ-DSMBXYKSSA-N

InChI

1S/C43H60N2O12/c1-9-11-13-21-31-42(6,7)38(50)39(51)43(54,57-31)28(10-2)40(52)44-23-17-16-19-26(4)36(55-8)27(5)37-35(49)34(48)30(56-37)20-15-12-14-18-25(3)33(47)32-29(46)22-24-45-41(32)53/h9,11-22,24,27-28,30-31,34-39,48-51,54H,10,23H2,1-8H3,(H,44,52)(H2,45,46,53)/b11-9+,14-12+,17-16+,20-15+,21-13+,25-18+,26-19+

SMILES string

CCC(C(=O)NC\C=C\C=C(/C)C(OC)C(C)C1OC(\C=C\C=C\C=C(/C)C(=O)C2=C(O)C=CNC2=O)C(O)C1O)C3(O)OC(\C=C\C=C\C)C(C)(C)C(O)C3O

biological source

Streptomyces collinus

form

powder

color

yellow

solubility

methanol: 1.90-2.10 mg/mL, clear, yellow

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

mode of action

protein synthesis | interferes

storage temp.

−20°C

Quality Level

200

General description

Chemical structure: polyene

Application

Kirromycin is a polyketide antibiotic which is produced by the actinomycetes Streptomyces collinus. Kirromycin has been used to stimulate GTPase action of EF-Tu in the absence of programmed ribosomes in Thermus thermophilus. Kirromycin is used to study bacterial protein synthesis at the level of elongation factor EF-Tu-GDP release.

Biochem/physiol Actions

Binding of kirromycin to EF-Tu prevents EF-TuGDP from being ejected from the ribosome, which immobilizes the ribsome, as well as all of the following ribosomes on the mRNA.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

涉药品监管产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
119M4018V
14151001
046M4040V
046M4040
040M4018

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Marina Pavlidou et al.
FEMS microbiology letters, 319(1), 26-33 (2011-03-16)
The main steps in the biosynthesis of complex secondary metabolites such as the antibiotic kirromycin are catalyzed by modular polyketide synthases (PKS) and/or nonribosomal peptide synthetases (NRPS). During antibiotic assembly, the biosynthetic intermediates are attached to carrier protein domains of
Mariorosario Masullo et al.
Biochemistry, 41(2), 628-633 (2002-01-10)
The G13A substitution in the G13XXXXGK[T,S] consensus sequence of the elongation factor 1 alpha from the archaeon Sulfolobus solfataricus (SsEF-1 alpha) was introduced in order to study the reasons for selective differences found in the homologous consensus element AXXXXGK[T,S] of
Pieter H Anborgh et al.
Biochemistry, 43(49), 15550-15556 (2004-12-08)
The antibiotic pulvomycin is an inhibitor of protein synthesis that prevents the formation of the ternary complex between elongation factor (EF-) Tu.GTP and aminoacyl-tRNA. In this report, novel aspects of its action on EF-Tu are described. Pulvomycin markedly affects the
Jan-Christian Schuette et al.
The EMBO journal, 28(6), 755-765 (2009-02-21)
We have used single-particle reconstruction in cryo-electron microscopy to determine a structure of the Thermus thermophilus ribosome in which the ternary complex of elongation factor Tu (EF-Tu), tRNA and guanine nucleotide has been trapped on the ribosome using the antibiotic
Lian N Olsthoorn-Tieleman et al.
Journal of bacteriology, 189(9), 3581-3590 (2007-03-06)
The antibiotic kirromycin inhibits prokaryotic protein synthesis by immobilizing elongation factor Tu (EF-Tu) on the elongating ribosome. Streptomyces ramocissimus, the producer of kirromycin, contains three tuf genes. While tuf1 and tuf2 encode kirromycin-sensitive EF-Tu species, the function of tuf3 is
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