K1507
Kirromycin from Streptomyces collinus
别名:
Antibiotic Myc-8003, Mocimycin
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关于此项目
经验公式（希尔记法）:
C43H60N2O12
化学文摘社编号:
分子量:
796.94
NACRES:
NA.85
PubChem Substance ID:
UNSPSC Code:
51102829
EC Number:
256-859-9
MDL number:
biological source
Streptomyces collinus
Quality Level
form
powder
color
yellow
solubility
methanol: 1.90-2.10 mg/mL, clear, yellow
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria
mode of action
protein synthesis | interferes
storage temp.
−20°C
SMILES string
CCC(C(=O)NC\C=C\C=C(/C)C(OC)C(C)C1OC(\C=C\C=C\C=C(/C)C(=O)C2=C(O)C=CNC2=O)C(O)C1O)C3(O)OC(\C=C\C=C\C)C(C)(C)C(O)C3O
InChI
1S/C43H60N2O12/c1-9-11-13-21-31-42(6,7)38(50)39(51)43(54,57-31)28(10-2)40(52)44-23-17-16-19-26(4)36(55-8)27(5)37-35(49)34(48)30(56-37)20-15-12-14-18-25(3)33(47)32-29(46)22-24-45-41(32)53/h9,11-22,24,27-28,30-31,34-39,48-51,54H,10,23H2,1-8H3,(H,44,52)(H2,45,46,53)/b11-9+,14-12+,17-16+,20-15+,21-13+,25-18+,26-19+
InChI key
HMSYAPGFKGSXAJ-DSMBXYKSSA-N
General description
Chemical structure: polyene
Application
Kirromycin is a polyketide antibiotic which is produced by the actinomycetes Streptomyces collinus. Kirromycin has been used to stimulate GTPase action of EF-Tu in the absence of programmed ribosomes in Thermus thermophilus. Kirromycin is used to study bacterial protein synthesis at the level of elongation factor EF-Tu-GDP release.
Biochem/physiol Actions
Binding of kirromycin to EF-Tu prevents EF-TuGDP from being ejected from the ribosome, which immobilizes the ribsome, as well as all of the following ribosomes on the mRNA.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
D Hughes
Journal of molecular biology, 297(2), 355-364 (2000-03-15)
The tufA and tufB genes in Salmonella typhimurium co-evolve by recombination and exchange of genetic material. A model is presented which predicts that co-evolution is achieved by gene conversions and chromosomal inversions. Analysis of recombinants reveals that conversion and inversion
A M Zuurmond et al.
Journal of molecular biology, 294(3), 627-637 (1999-12-28)
For clarification of the action of a new antibiotic, the analysis of resistant mutants is often indispensable. For enacyloxin IIa we discovered four resistant elongation factor Tu (EF-Tu) species in Escherichia coli with the mutations Q124K, G316D, Q329H, and A375T
Structural biology. A glimpse into tmRNA-mediated ribosome rescue.
Sean D Moore et al.
Science (New York, N.Y.), 300(5616), 72-73 (2003-04-05)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| K1507-5MG | 04061833271896 |