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Merck
CN

K1507

Sigma-Aldrich

Kirromycin from Streptomyces collinus

别名:

Antibiotic Myc-8003, Mocimycin

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关于此项目

经验公式（希尔记法）:
C43H60N2O12
化学文摘社编号:
50935-71-2
分子量:
796.94
EC 号:
256-859-9
MDL编号:
MFCD00467139
UNSPSC代码:
51102829
PubChem化学物质编号:
24896207
NACRES:
NA.85

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生物来源

Streptomyces collinus

质量水平

200

表单

powder

颜色

yellow

溶解性

methanol: 1.90-2.10 mg/mL, clear, yellow

抗生素抗菌谱

Gram-negative bacteria
Gram-positive bacteria

作用机制

protein synthesis | interferes

储存温度

−20°C

SMILES字符串

CCC(C(=O)NC\C=C\C=C(/C)C(OC)C(C)C1OC(\C=C\C=C\C=C(/C)C(=O)C2=C(O)C=CNC2=O)C(O)C1O)C3(O)OC(\C=C\C=C\C)C(C)(C)C(O)C3O

InChI

1S/C43H60N2O12/c1-9-11-13-21-31-42(6,7)38(50)39(51)43(54,57-31)28(10-2)40(52)44-23-17-16-19-26(4)36(55-8)27(5)37-35(49)34(48)30(56-37)20-15-12-14-18-25(3)33(47)32-29(46)22-24-45-41(32)53/h9,11-22,24,27-28,30-31,34-39,48-51,54H,10,23H2,1-8H3,(H,44,52)(H2,45,46,53)/b11-9+,14-12+,17-16+,20-15+,21-13+,25-18+,26-19+

InChI key

HMSYAPGFKGSXAJ-DSMBXYKSSA-N

一般描述

Chemical structure: polyene

应用

Kirromycin is a polyketide antibiotic which is produced by the actinomycetes Streptomyces collinus. Kirromycin has been used to stimulate GTPase action of EF-Tu in the absence of programmed ribosomes in Thermus thermophilus. Kirromycin is used to study bacterial protein synthesis at the level of elongation factor EF-Tu-GDP release.

生化/生理作用

Binding of kirromycin to EF-Tu prevents EF-TuGDP from being ejected from the ribosome, which immobilizes the ribsome, as well as all of the following ribosomes on the mRNA.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

涉药品监管产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
119M4018V
14151001
046M4040V
046M4040
040M4018

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D Hughes
Journal of molecular biology, 297(2), 355-364 (2000-03-15)
The tufA and tufB genes in Salmonella typhimurium co-evolve by recombination and exchange of genetic material. A model is presented which predicts that co-evolution is achieved by gene conversions and chromosomal inversions. Analysis of recombinants reveals that conversion and inversion
A M Zuurmond et al.
Journal of molecular biology, 294(3), 627-637 (1999-12-28)
For clarification of the action of a new antibiotic, the analysis of resistant mutants is often indispensable. For enacyloxin IIa we discovered four resistant elongation factor Tu (EF-Tu) species in Escherichia coli with the mutations Q124K, G316D, Q329H, and A375T
Structural biology. A glimpse into tmRNA-mediated ribosome rescue.
Sean D Moore et al.
Science (New York, N.Y.), 300(5616), 72-73 (2003-04-05)
Steven T Gregory et al.
RNA (New York, N.Y.), 15(2), 208-214 (2008-12-20)
Codon recognition by aminoacyl-tRNA on the ribosome triggers a process leading to GTP hydrolysis by elongation factor Tu (EF-Tu) and release of aminoacyl-tRNA into the A site of the ribosome. The nature of this signal is largely unknown. Here, we
Marina Pavlidou et al.
FEMS microbiology letters, 319(1), 26-33 (2011-03-16)
The main steps in the biosynthesis of complex secondary metabolites such as the antibiotic kirromycin are catalyzed by modular polyketide synthases (PKS) and/or nonribosomal peptide synthetases (NRPS). During antibiotic assembly, the biosynthetic intermediates are attached to carrier protein domains of
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